Molecular structure of MRN-ATM Pathway Inhibitor, Mirin, CAS Number: 299953-00-7
MRN-ATM Pathway Inhibitor, Mirin (CAS 299953-00-7)
See product citations (4)
Alternate Names:
5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-on
Application:
MRN-ATM Pathway Inhibitor, Mirin is an inhibitor of Mre-11 and cell cycle arresting compound
CAS Number:
299953-00-7
Purity:
>95%
Molecular Weight:
220.35
Molecular Formula:
C10H8N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MRN-ATM Pathway Inhibitor, Mirin, may act to prevent Mre11-Rad50-Nbs1 (MRN)-dependent activation of ataxia-telangiectasia mutated (ATM) without affecting ATM protein kinase activity. Mirin inhibits MRN by blocking the nuclease activity of Mre11, which in turn prevents the MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Other experiments have noted that inhibiting Mre11 also causes a reduction in the efficiency of non-homologous end joining. The MRN-ATM pathway has been reported to be essential for DNA damage detection and maintenance of genome stability during DNA replication. This pathway also promotes homology-dependent DNA repair, activates ATM, and is essential for cell viability. In vitro, mirin may act to induce cell-cycle arrest at the G2 phase, override the G2/M checkpoint, and inhibit homology-directed DNA repair.
MRN-ATM Pathway Inhibitor, Mirin (CAS 299953-00-7) References
- A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. | Dupré, A., et al. 2008. Nat Chem Biol. 4: 119-25. PMID: 18176557
- Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. | Garner, KM., et al. 2009. Nat Chem Biol. 5: 129-30; author reply 130. PMID: 19219009
- MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. | Roques, C., et al. 2009. EMBO J. 28: 2400-13. PMID: 19609304
- Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. | Rass, E., et al. 2009. Nat Struct Mol Biol. 16: 819-24. PMID: 19633668
- ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining. | Rahal, EA., et al. 2010. Cell Cycle. 9: 2866-77. PMID: 20647759
- BRCA1 requirement for the fidelity of plasmid DNA double-strand break repair in cultured breast epithelial cells. | Thompson, EG., et al. 2012. Environ Mol Mutagen. 53: 32-43. PMID: 22170030
- DNA damage repair genes controlling human papillomavirus (HPV) episome levels under conditions of stability and extreme instability. | Edwards, TG., et al. 2013. PLoS One. 8: e75406. PMID: 24098381
- Mirin: identifying microRNA regulatory modules in protein-protein interaction networks. | Yang, KC., et al. 2014. Bioinformatics. 30: 2527-8. PMID: 24794934
- Expression of the Mre11-Rad50-Nbs1 complex in cisplatin nephrotoxicity. | Kim, YJ., et al. 2015. Environ Toxicol Pharmacol. 40: 12-7. PMID: 26056972
- Stalled replication forks within heterochromatin require ATRX for protection. | Huh, MS., et al. 2016. Cell Death Dis. 7: e2220. PMID: 27171262
- Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs. | Berte, N., et al. 2016. Mol Cancer Ther. 15: 2665-2678. PMID: 27474153
- AND-1 fork protection function prevents fork resection and is essential for proliferation. | Abe, T., et al. 2018. Nat Commun. 9: 3091. PMID: 30082684
- XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks. | Benjamin, R., et al. 2022. Int J Mol Sci. 23: PMID: 35054780
- Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. | Alblihy, A., et al. 2022. NPJ Precis Oncol. 6: 51. PMID: 35853939
- Giardia duodenalis carries out canonical homologous recombination and single-strand annealing. | García-Lepe, UO., et al. 2022. Res Microbiol. 173: 103984. PMID: 35944795
Inhibitor of:
2610002J02Rik, 3010026O09Rik, 4931417G12Rik, 53BP1, C17orf53, C9orf102, Cdc45, DNA pol θ, Etaa1, FAM175B, GBDR1, Histone H2AX, hPMS1, MDC1, MRE11, MRE11_Mre11, MUS81, MUTYH, NBS1, NSE2, PC-PLD4, PIERCE 1, PTIP, Rad50, RAD54L2, Rad57, Rif1, RMI2, RNF168, RNF8, RTEL1, Scc1, SLX1A/B_SLX1, SmarcAL1, SMC1α, Spo11, Srs2, TDP1, TEX38, TIPIN, TTI1, XPV, and XRCC4.Activator of:
ASF1A, ATRIP, Dicer, DNAH5, FAM111A, FANCM, Hus1, I-SceI, NBS1, Rad1, Rad18, SLX1A/B_SLX1, TopBP1, XRCC3, ZRANB3, and ZSWIM7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRN-ATM Pathway Inhibitor, Mirin, 10 mg | sc-203144 | 10 mg | $141.00 |