ZNF865 Activators
Chemical activators of ZNF865 can engage a variety of cellular signaling pathways to exert their effects. Forskolin, by directly activating adenylate cyclase, leads to an increase in intracellular cAMP levels. The elevated cAMP in turn activates protein kinase A (PKA), which can phosphorylate a broad spectrum of substrates including ZNF865, thus leading to its activation. Similarly, IBMX, by inhibiting a range of phosphodiesterases, prevents the breakdown of cAMP, which sustains and enhances PKA activity. This amplified PKA activity can subsequently contribute to the phosphorylation and activation of ZNF865. Directly adding cyclic AMP to the system bypasses the upstream activators and directly engages PKA, which then can target ZNF865 among other proteins.
The activation of protein kinase C (PKC) by Phorbol 12-myristate 13-acetate (PMA) introduces phosphorylation events that can lead to the activation of ZNF865. Calyculin A and Okadaic Acid, by inhibiting protein phosphatases, can result in the accumulation of phosphorylated proteins, which could include ZNF865, leading to its activation. The modulation of intracellular calcium levels by Ionomycin and Thapsigargin can activate calcium-dependent kinases, which then may phosphorylate and activate ZNF865. Anisomycin, known to activate stress-activated protein kinases (SAPKs)/JNKs, could promote the phosphorylation and consequent activation of ZNF865 within the cell's stress response mechanisms. Epigallocatechin gallate (EGCG) inhibits phosphodiesterases, leading to increased cAMP levels, thus enhancing the activity of PKA, which in turn can activate ZNF865 through phosphorylation. The unique chemical 4-Alpha-Phorbol 12,13-didecanoate, although not a direct activator of PKC, can influence other pathways that converge on the phosphorylation and presumed activation of ZNF865. Zinc Pyrithione can elevate intracellular zinc levels, which may influence metal-responsive transcription factors or other zinc-activated proteins to interact with and promote the activation of ZNF865.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly activates adenylate cyclase, leading to increased cAMP levels which activate PKA, potentially resulting in the phosphorylation and functional activation of ZNF865. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-selective phosphodiesterase inhibitor, increases cAMP levels, thereby enhancing PKA activity which could phosphorylate and activate ZNF865. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
As a second messenger, cAMP activates PKA; activated PKA can then phosphorylate ZNF865, which may lead to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates PKC, which could phosphorylate and thereby activate ZNF865 as part of downstream signaling. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation levels within the cell, which may include the phosphorylation and activation of ZNF865. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Inhibits protein phosphatases, particularly PP1 and PP2A, which could lead to sustained phosphorylation and activation of ZNF865. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium levels, which can activate calcium-dependent kinases that may phosphorylate and activate ZNF865. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Inhibits SERCA, causing increased cytosolic calcium levels which can activate calcium-dependent kinases, potentially resulting in the phosphorylation and activation of ZNF865. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Activates SAPKs/JNKs which could lead to the phosphorylation and subsequent activation of ZNF865 within the stress response pathway. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Inhibits phosphodiesterases, leading to increased cAMP levels and subsequent activation of PKA which might phosphorylate and activate ZNF865. | ||||||