ZNF597 Activators
The chemical class of ZNF597 activators primarily consists of compounds that modulate epigenetic mechanisms, particularly histone acetylation and DNA methylation, which are crucial for the regulation of gene expression. Histone deacetylase inhibitors such as vorinostat, trichostatin A, and panobinostat activate ZNF597 by inhibiting histone deacetylation, resulting in enhanced transcriptional activity. Similarly, DNA methyltransferase inhibitors like decitabine and azacitidine activate ZNF597 by blocking DNA methylation, thereby promoting transcription.
Additionally, compounds like entinostat and romidepsin, which are specific inhibitors of class I histone deacetylases, exert their activatory effects on ZNF597 by modulating histone acetylation levels. Furthermore, entacapone indirectly activates ZNF597 by inhibiting catechol-O-methyltransferase activity, which influences transcriptional regulation. Valproic acid, apart from being a histone deacetylase inhibitor, also affects GABA metabolism, contributing to the activation of ZNF597.
Moreover, caffeic acid phenethyl ester (CAPE) activates ZNF597 by modulating intracellular signaling pathways involved in gene expression regulation, highlighting its role as a potential indirect activator. Apicidin, a cyclic tetrapeptide histone deacetylase inhibitor, activates ZNF597 by inhibiting histone deacetylation, thereby enhancing its transcriptional activity. Collectively, these compounds represent a diverse class of ZNF597 activators that target various cellular mechanisms involved in gene expression regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, also known as suberanilohydroxamic acid (SAHA), is a histone deacetylase inhibitor that can activate ZNF597 by modulating histone acetylation levels. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a potent histone deacetylase inhibitor, activates ZNF597 by inhibiting histone deacetylation, thereby promoting the transcriptional activity of ZNF597. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat, another histone deacetylase inhibitor, activates ZNF597 by modulating histone acetylation levels, leading to enhanced transcriptional activity of ZNF597. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat, a class I histone deacetylase inhibitor, activates ZNF597 by promoting histone acetylation, which facilitates the transcriptional activity of ZNF597. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin, a cyclic peptide histone deacetylase inhibitor, activates ZNF597 by inhibiting histone deacetylation, thereby enhancing the transcriptional activity of ZNF597. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat, a hydroxamate-type histone deacetylase inhibitor, activates ZNF597 by modulating histone acetylation levels, leading to increased transcriptional activity of ZNF597. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine, a DNA methyltransferase inhibitor, activates ZNF597 by inhibiting DNA methylation, which promotes the transcriptional activity of ZNF597. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacitidine, another DNA methyltransferase inhibitor, activates ZNF597 by inhibiting DNA methylation, leading to enhanced transcriptional activity of ZNF597. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, a histone deacetylase inhibitor and GABA transaminase inhibitor, activates ZNF597 by modulating histone acetylation levels and GABA metabolism, respectively. | ||||||
Apicidin | 183506-66-3 | sc-202061 sc-202061A | 1 mg 5 mg | $110.00 $343.00 | 9 | |
Apicidin, a cyclic tetrapeptide histone deacetylase inhibitor, activates ZNF597 by inhibiting histone deacetylation, leading to enhanced transcriptional activity of ZNF597. | ||||||