ZNF543 Activators
ZNF543 can induce its activity through a variety of intracellular signaling pathways. Forskolin, by raising intracellular cyclic AMP (cAMP) levels, activates protein kinase A (PKA), which can phosphorylate and activate ZNF543. The mechanism is similar with Isoproterenol and Dibutyryl-cAMP, both of which increase cAMP levels, subsequently activating PKA and enhancing the phosphorylation state of ZNF543. Epidermal Growth Factor (EGF) operates through a different mechanism, binding to its receptor EGFR and initiating a cascade that activates the MAPK/ERK pathway, culminating in the phosphorylation and activation of ZNF543. Phorbol 12-myristate 13-acetate (PMA) stimulates protein kinase C (PKC), another kinase that can phosphorylate a range of substrates including ZNF543, altering its activity.
ZNF543 activation include those mediated by changes in intracellular calcium levels. Ionomycin elevates calcium concentrations inside cells, which can activate calcium-dependent kinases capable of modifying ZNF543. Bradykinin also raises intracellular calcium levels through its G protein-coupled receptors and the subsequent production of inositol trisphosphate (IP3), which may lead to the activation of ZNF543. Insulin triggers the PI3K/Akt pathway that can phosphorylate various proteins, possibly leading to modifications of ZNF543. Lithium chloride acts indirectly by inhibiting GSK-3β, affecting the Wnt signaling pathway and possibly leading to the activation of ZNF543. Sodium butyrate alters chromatin structure, potentially enhancing ZNF543's ability to bind DNA. Finally, Calyculin A helps maintain the phosphorylated state of proteins by inhibiting protein phosphatases known to dephosphorylate proteins like ZNF543.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate target proteins, including ZNF543, leading to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a wide range of cellular proteins. PKC-mediated phosphorylation can lead to the activation of ZNF543 through changes in its conformation or interaction with other cellular components. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. Such pathways may involve calmodulin or calcium/calmodulin-dependent protein kinases, which could phosphorylate and activate ZNF543. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin receptor activation triggers the PI3K/Akt signaling pathway, which can result in the phosphorylation of various proteins. Akt may phosphorylate substrates that interact with or modify ZNF543, leading to its functional activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is an agonist of beta-adrenergic receptors, leading to the activation of adenylate cyclase and an increase in cAMP levels. The subsequent activation of PKA can phosphorylate ZNF543, enhancing its functional activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that directly activates PKA. PKA activation can result in the phosphorylation of ZNF543, which may lead to an increase in its functional activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to nuclear receptors that can regulate gene transcription. The activation of these receptors can lead to alterations in the cellular milieu that support the functional activation of ZNF543 by post-translational modifications. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates its G protein-coupled receptors, leading to the activation of phospholipase C and the generation of inositol trisphosphate (IP3). The IP3 pathway can lead to calcium mobilization, potentially activating ZNF543 through calcium-dependent kinases. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a negative regulator of the Wnt signaling pathway. Inhibition of GSK-3β leads to the stabilization and activation of β-catenin, which may interact with and activate ZNF543 as part of transcriptional regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that leads to a more relaxed chromatin structure and can affect transcription factor access and activity. This can support the functional activation of ZNF543 by enhancing its DNA binding capacity. | ||||||