ZNF525 Inhibitors
Chemical inhibitors of ZNF525 function through various interactions with signaling pathways and enzymatic activities that are crucial for the protein's role in cellular processes. PD168393 directly targets the EGFR tyrosine kinase, an enzyme that can phosphorylate substrates such as ZNF525, thus modulating its activity. By inhibiting EGFR, PD168393 can prevent the phosphorylation of ZNF525, leading to a decrease in its downstream signaling and regulatory functions. SB431542, on the other hand, acts by inhibiting ALK5, a TGF-β type I receptor, which might be involved in the same cellular pathways as ZNF525. The inhibition of ALK5 by SB431542 disrupts the TGF-β signaling pathway, which can consequently diminish the transcriptional regulation by ZNF525. Similarly, SP600125 inhibits JNK, which may reduce the activity of AP-1, a potential component of the transcriptional regulation pathways involving ZNF525, thereby inhibiting the functional role of ZNF525 in gene expression.
Other inhibitors like GW5074 and U0126 focus on the MAPK/ERK pathway. GW5074 inhibits Raf-1 kinase, while U0126 inhibits MEK1/2, both of which are important components of the MAPK/ERK pathway. ZNF525 may play a role in this pathway, and the inhibition of these kinases can impair the signaling cascade, which can lead to the inhibition of ZNF525's transcriptional regulation functions. LY294002 and Wortmannin target the PI3K/Akt signaling pathway by inhibiting PI3K. The PI3K/Akt pathway can intersect with the pathways where ZNF525 is involved; thus, by inhibiting PI3K, these chemicals can block the signaling that may be necessary for ZNF525's role in transcriptional regulation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 168393 | 194423-15-9 | sc-222138 | 1 mg | $162.00 | 4 | |
Inhibits EGFR tyrosine kinase activity which may interact with ZNF525 by phosphorylation, thus inhibiting ZNF525 downstream signaling involved in transcriptional regulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibits ALK5, a TGF-β type I receptor, which could be involved in cellular pathways where ZNF525 acts as a transcriptional regulator; by inhibiting ALK5, this would disrupt TGF-β signaling and consequently ZNF525-mediated transcription. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
Inhibits JNK, potentially reducing AP-1 activity which could be a component of the transcriptional regulation pathways in which ZNF525 operates, thus inhibiting ZNF525's functional role in gene expression. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
Inhibits Raf-1 kinase which is part of the MAPK/ERK pathway; ZNF525 might be involved in this pathway, and inhibition of Raf-1 would disrupt the signaling cascade, leading to the inhibition of ZNF525's transcriptional regulation functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, thus blocking the PI3K/Akt signaling pathway that may intersect with pathways involving ZNF525, leading to functional inhibition of ZNF525's role in transcriptional regulation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Inhibits Src family kinases which could interact with signaling pathways regulated by ZNF525, leading to functional inhibition of ZNF525's role in these pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibits MEK1/2, impairing the MAPK/ERK pathway; ZNF525 could be involved in this pathway for its transcriptional regulation functions, and inhibition of MEK1/2 would inhibit ZNF525's associated activities. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, which is part of the MAPK/ERK pathway; ZNF525 could be involved in this pathway through its transcriptional regulatory roles, and inhibition of MEK would thus inhibit ZNF525's function in cell proliferation and differentiation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibits PI3K like LY294002; by stopping PI3K signaling, it would impede the cellular processes where ZNF525 is functionally involved, leading to its inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, a downstream target of PI3K, and by doing so, it would disrupt cellular growth processes that ZNF525 may influence, leading to a functional inhibition of ZNF525 activities related to cell growth and survival. | ||||||