ZNF230 Activators
ZNF230 can engage various cellular signaling pathways to promote the functional activation of the protein. Forskolin, through its ability to directly activate adenylyl cyclase, leads to an elevation of intracellular cAMP levels, which in turn activates protein kinase A (PKA). The activated PKA can then phosphorylate transcription factors that may interact with ZNF230, enhancing its transcriptional activity. Similarly, dibutyryl-cAMP (db-cAMP), a membrane-permeable analog of cAMP, also activates PKA, which could then target transcription factors associated with ZNF230, leading to its activation. Ionomycin increases intracellular calcium levels and can activate calcium-dependent protein kinases that may phosphorylate ZNF230, thus promoting its activity.
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which phosphorylates a range of target proteins, and this cascade could include ZNF230, resulting in its activation. The activation of the PI3K/Akt signaling pathway by insulin has numerous downstream effects, including the activation of transcription factors that may influence the activity of ZNF230. The Epidermal Growth Factor (EGF) stimulates the MAPK/ERK pathway, leading to the activation of transcription factors that may work in concert with ZNF230. Calmodulin, when complexed with calcium, can activate a suite of kinases and phosphatases, which might target ZNF230 or its cofactors for activation. Retinoic acid binds to nuclear receptors that may interact with the regulatory regions of genes, potentially enhancing the transcriptional activity of ZNF230 by recruiting coactivators. Sphingosine 1-phosphate (S1P) can activate sphingosine kinase, which could lead to the activation of proteins that modulate ZNF230's function, thereby activating it. Arachidonic acid, upon metabolism to various eicosanoids, activates signaling pathways that could lead to the phosphorylation and activation of ZNF230. Lastly, hydrogen peroxide (H2O2), as a signaling molecule, activates various kinases through oxidative mechanisms that may include proteins governing the activity regulation of ZNF230
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels, which can activate calcium-dependent protein kinases that may phosphorylate ZNF230, enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate a wide range of target proteins, possibly including ZNF230, leading to the protein's functional activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which has numerous downstream effects, including the activation of transcription factors that may interact with ZNF230, leading to its functional activation. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP acts as a second messenger to activate protein kinase A (PKA), which may phosphorylate ZNF230 or associated regulatory proteins, leading to ZNF230 activation. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calmodulin, upon binding calcium, can activate various kinases and phosphatases which could potentially target ZNF230 or its cofactors for activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds its nuclear receptors, which can interact with the regulatory regions of genes and may enhance the transcriptional activity of ZNF230 by recruiting coactivators. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P can activate sphingosine kinase, which in turn might phosphorylate and activate proteins that modulate the function of ZNF230, leading to its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a membrane-permeable cAMP analog that activates PKA, and PKA can then phosphorylate transcription factors or coactivators associated with ZNF230, promoting its activity. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid can be metabolized to produce various eicosanoids that activate signaling pathways, potentially leading to the phosphorylation and activation of ZNF230. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
H2O2 serves as a signaling molecule that can activate various kinases through oxidative mechanisms, which may include the activation of ZNF230 or proteins that regulate ZNF230 activity. | ||||||