ZNF160 Inhibitors

The inhibitors listed above are proposed based on their ability to influence ZNF160 activity or associated transcriptional regulation pathways. Zinc finger proteins like ZNF160 are often key players in gene expression control, interacting with DNA, RNA, or other proteins to regulate transcription. BET bromodomain inhibitors such as JQ1 and I-BET151 disrupt the interactions between transcription factors and chromatin, which affects pathways involving ZNF160. HDAC inhibitors, including Suberoylanilide Hydroxamic Acid, Trichostatin A, and Panobinostat, alter chromatin structure and gene expression, impacting ZNF160's transcriptional regulation functions. DNA methyltransferase inhibitors like 5-Azacytidine and 5-Aza-2′-Deoxycytidine can influence DNA methylation patterns, affecting transcriptional activities where ZNF160 is involved. EZH2 inhibitors (GSK126, 3-Deazaneplanocin) could impact ZNF160's function in gene repression through the PRC2 complex.

Additionally, compounds targeting key cellular signaling molecules, such as LY 294002 (PI3K inhibitor) and PD 98059 (MEK inhibitor), might indirectly affect ZNF160 by altering signaling pathways that influence transcriptional regulation. These compounds offer insights into possible mechanisms to modulate ZNF160's function in transcriptional regulation, underscoring the complex interplay of chromatin remodeling, gene expression, and signaling pathways in the regulation of zinc finger protein-mediated activities.