Zizimin-1 Activators
Zizimin-1 Activators belong to a fascinating class of chemical compounds that have garnered significant attention in the field of molecular biology and cell signaling research. Zizimin-1, also known as Dock9, is a crucial protein in the Rho family of small GTPases, and it plays a pivotal role in regulating various cellular processes, particularly those related to cytoskeletal dynamics and cell migration. Zizimin-1 is primarily expressed in immune cells, neurons, and other tissues, where it exerts its influence on cellular functions. Activators of Zizimin-1 are molecules that have been identified for their ability to modulate the activity of this protein, thereby influencing downstream signaling pathways.
These activators work by binding to Zizimin-1 and inducing a conformational change in its structure, leading to the activation of its GEF (Guanine Nucleotide Exchange Factor) domain. This activation, in turn, triggers the exchange of GDP (guanosine diphosphate) for GTP (guanosine triphosphate) on specific Rho GTPases. As a consequence, Zizimin-1 activators stimulate the activation of Rho GTPases, which are critical regulators of the actin cytoskeleton and cell motility. This process can have profound effects on cell shape, adhesion, and migration, making Zizimin-1 activators valuable tools for researchers investigating cellular processes like immune cell chemotaxis, axon guidance, and neuronal plasticity. While these compounds hold great potential for advancing our understanding of cell biology, it's important to note that their specific mechanisms of action and precise structural features may vary, and ongoing research continues to uncover the intricacies of how they interact with Zizimin-1 to modulate its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which can lead to the activation of small GTPases by promoting their translocation to the plasma membrane. Since Zizimin-1 functions as a guanine nucleotide exchange factor (GEF) for small GTPases, PMA-induced activation of PKC can enhance the activity of Zizimin-1 by increasing its substrate (GTPases) availability at the membrane. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels and subsequently activating PKA. PKA can phosphorylate various proteins, potentially including those that interact with or regulate Zizimin-1, thereby enhancing Zizimin-1 GEF activity for small GTPases like Cdc42. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a potent antioxidant that inhibits certain types of kinases. By inhibiting these kinases, EGCG could reduce negative regulatory phosphorylation of Zizimin-1 or its interacting partners, leading to an enhanced GEF activity of Zizimin-1. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase II (CaMKII), which may phosphorylate regulatory proteins of Zizimin-1, thus potentially enhancing its GEF activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl inhibits GSK-3, which can lead to the accumulation of β-catenin. Accumulated β-catenin may enter the nucleus and activate transcription of genes, possibly including those encoding proteins that interact with or regulate Zizimin-1, thus enhancing its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P binds to its G-protein coupled receptors, leading to downstream signaling events that can include activation of small GTPases. As Zizimin-1 is a GEF for small GTPases, S1P signaling can indirectly enhance Zizimin-1 activity by increasing its substrate availability. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
H2O2 serves as a signaling molecule that can lead to the oxidative modification of proteins. This can result in the activation of signaling pathways that potentially include those regulating Zizimin-1 or its substrates, thereby enhancing Zizimin-1’s GEF activity. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is a PKC modulator that can activate or inhibit PKC depending on the context. By activating PKC, Bryostatin 1 may promote the activation of pathways that increase the membrane localization of small GTPases, thus enhancing the GEF activity of Zizimin-1. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol affects the trafficking and localization of signaling molecules, including small GTPases. This stabilization may lead to enhanced interaction between Zizimin-1 and its substrates, increasing its GEF activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
Analog of cAMP that activates PKA, leading to phosphorylation of proteins that could interact with or regulate Zizimin-1. This activation may result in an increase in Zizimin-1 GEF activity towards small GTPases like Cdc42. | ||||||