Zfp870 Activators
Zfp870, a DNA-binding transcription factor with predicted involvement in the regulation of transcription by RNA polymerase II, plays a crucial role in gene expression within the nucleus. The protein is anticipated to exhibit DNA-binding activity, specifically to cis-regulatory regions, suggesting its function in orchestrating precise transcriptional regulation.
The activation of Zfp870 is intricately linked to epigenetic modifications and chromatin dynamics. Various chemicals, such as Azacitidine and 5-Azacytidine, act as potential indirect activators by demethylating cis-regulatory regions, thereby promoting Zfp870's access to regulatory elements and facilitating RNA polymerase II-specific DNA binding. HDAC inhibitors like Trichostatin A and SAHA impact histone acetylation, altering chromatin structure to enhance Zfp870's binding to DNA and promoting its transcriptional regulatory function. Natural compounds like Resveratrol, Curcumin, and Betulinic Acid exert their effects through anti-inflammatory mechanisms and epigenetic modulation, influencing chromatin accessibility for Zfp870 binding and enhancing its role in transcriptional regulation. Understanding the intricate mechanisms of Zfp870 activation provides valuable insights into the complex landscape of gene expression control in various cellular processes within the nucleus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor impacting DNA methylation. Potential indirect activator of Zfp870 by demethylating cis-regulatory regions, promoting RNA polymerase II-specific DNA binding. Azacitidine's role involves epigenetic modifications that enhance Zfp870's access to regulatory elements, facilitating transcriptional regulation in the nucleus. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Polyphenolic compound with diverse cellular effects. Potential indirect activator of Zfp870 through its antioxidant and epigenetic modulating properties. Resveratrol's role may involve influencing RNA polymerase II-mediated transcription by altering the chromatin landscape, promoting Zfp870 binding to cis-regulatory regions and enhancing its transcriptional regulatory function in the nucleus. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor impacting epigenetic regulation. Potential indirect activator of Zfp870 by inhibiting HDACs, leading to histone acetylation and altered chromatin structure in cis-regulatory regions. Trichostatin A's role involves epigenetic modifications that enhance Zfp870 binding to DNA, promoting transcriptional regulation by RNA polymerase II. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitor affecting chromatin remodeling. Potential indirect activator of Zfp870 by inhibiting HDACs, promoting histone acetylation, and influencing RNA polymerase II-specific DNA binding. SAHA's role involves epigenetic modifications that enhance Zfp870 binding to cis-regulatory regions, facilitating its transcriptional regulatory function in the nucleus. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Natural polyphenol affecting multiple signaling pathways. Potential indirect activator of Zfp870 through its anti-inflammatory and epigenetic modulation, influencing the transcriptional regulation by RNA polymerase II. Curcumin's role may involve suppressing inflammatory pathways and modifying chromatin accessibility, enhancing Zfp870 activity in the nucleus. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor impacting gene transcription. Potential indirect activator of Zfp870 by inhibiting bromodomain proteins, altering chromatin structure, and influencing RNA polymerase II activity. JQ1's role involves modulating the epigenetic landscape to facilitate Zfp870 binding to cis-regulatory regions and enhance its transcriptional regulatory function in the nucleus. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
HDAC inhibitor modulating gene expression. Potential indirect activator of Zfp870 by inhibiting HDACs, leading to increased histone acetylation and altered chromatin accessibility for RNA polymerase II. Sodium Butyrate's role involves epigenetic modifications that enhance Zfp870 binding to cis-regulatory regions, promoting transcriptional regulation in the nucleus. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Natural triterpenoid impacting multiple pathways. Potential indirect activator of Zfp870 through its anti-inflammatory and epigenetic modulating properties. Betulinic Acid's role involves influencing RNA polymerase II-mediated transcription by modifying chromatin accessibility, promoting Zfp870 binding to cis-regulatory regions and enhancing its transcriptional regulatory function in the nucleus. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
PARP inhibitor impacting chromatin structure. Potential indirect activator of Zfp870 through PARP inhibition, influencing RNA polymerase II-mediated transcription. A-485's role involves modulating the chromatin environment to facilitate Zfp870 binding to cis-regulatory regions and enhance its transcriptional regulatory function in the nucleus. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor influencing DNA methylation. Potential indirect activator of Zfp870 by demethylating cis-regulatory regions, promoting RNA polymerase II-specific DNA binding. Decitabine's role involves epigenetic modifications that enhance Zfp870's access to regulatory elements, facilitating transcriptional regulation in the nucleus. | ||||||