Zfp808 Activators
Zfp808 activators are a diverse group of chemical compounds that share the common feature of being able to enhance the functional activity of zinc finger protein 808 (Zfp808), a transcription factor implicated in the regulation of gene expression. These activators achieve their effect through a variety of cellular mechanisms, often influencing signaling pathways and transcriptional machinery within the cell. The biochemical nature of Zfp808 activators is eclectic, ranging from small organic molecules to lipids and including both naturally occurring substances and synthetic chemicals. Their modes of action can be direct, such as by binding to and stabilizing the Zfp808 protein itself, or indirect, by modulating the activity of enzymes, receptors, or other proteins that govern the transcriptional activity of Zfp808. For instance, activators like forskolin and IBMX work by increasing intracellular levels of cAMP, a second messenger that activates protein kinase A (PKA), which can then phosphorylate transcription factors and coactivators that enhance Zfp808 activity.
The biological impact of Zfp808 activators is rooted in their ability to influence the expression of genes that are under the regulatory umbrella of Zfp808. This is achieved through various pathways that converge on the transcriptional regulation machinery. Some activators, such as rosiglitazone and pioglitazone, function as agonists for nuclear receptors like PPARγ, which upon activation can bind to DNA response elements and modulate gene expression. Other compounds, such as curcumin and resveratrol, may exert their effects through the modulation of signaling pathways like NF-kB, which is known to play a significant role in the regulation of many genes, including those controlled by Zfp808. Additionally, compounds like sodium butyrate act as histone deacetylase (HDAC) inhibitors, leading to changes in chromatin structure that can result in the increased transcription of genes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, which increases intracellular cAMP levels. Elevated cAMP activates PKA, which can then phosphorylate transcription factors that enhance the expression of zinc finger protein 808, leading to its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP. This results in increased levels of these cyclic nucleotides and subsequent activation of PKA and PKG, potentially enhancing the activity of zinc finger protein 808 through phosphorylation of associated transcription factors. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone, a PPARγ agonist, influences the transcription of various genes including those involved in lipid metabolism. Activation of PPARγ can lead to an upregulation of transcription factors that increase the expression of zinc finger protein 808. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid, a monounsaturated fatty acid, can serve as a ligand for peroxisome proliferator-activated receptors (PPARs). Upon activation, PPARs may enhance the transcription of genes including those related to zinc finger protein 808 functional activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts on retinoic acid receptors (RARs), which dimerize with retinoid X receptors (RXRs) and bind to retinoic acid response elements (RAREs) in the promoter regions of target genes, potentially including those regulating zinc finger protein 808. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can influence various signaling pathways including NF-kB, which is implicated in the regulation of gene expression. By modulating this pathway, curcumin can enhance the functional activity of genes regulated by NF-kB, possibly including zinc finger protein 808. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone acts as a glucocorticoid receptor agonist. The activated receptor can translocate to the nucleus and act as a transcription factor, potentially upregulating genes that are involved in enhancing the functional activity of zinc finger protein 808. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can alter various cellular processes by modulating the phosphorylation state of proteins. This compound may influence the expression and activity of transcription factors that regulate zinc finger protein 808. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate is an HDAC inhibitor that leads to an increase in acetylation of histones, resulting in a more relaxed chromatin structure and enhanced transcription of certain genes, possibly including those related to zinc finger protein 808 activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to activate sirtuins, which can deacetylate histones and transcription factors. This action can lead to the upregulation of genes, potentially influencing the functional activity of zinc finger protein 808. | ||||||