Zfp781 Activators
Zfp781, a zinc finger protein, exerts its function in transcriptional regulation by RNA polymerase II through DNA-binding transcription factor activity. As a nucleus-localized protein involved in the regulation of transcription, Zfp781 plays a pivotal role in the modulation of gene expression. The activation of Zfp781 is intricately linked to epigenetic modifications and chromatin dynamics. Several chemicals, such as Trichostatin A, Curcumin, and JQ1, act as potential indirect activators of Zfp781 by influencing histone acetylation, DNA methylation, and chromatin accessibility, thereby enhancing its binding to cis-regulatory regions and promoting transcriptional regulation in the nucleus. These compounds target key cellular pathways involved in epigenetic regulation, creating a conducive environment for Zfp781 to exert its transcriptional regulatory function.
The general mechanisms of Zfp781 activation involve the modulation of epigenetic marks, chromatin remodeling, and the accessibility of cis-regulatory regions. HDAC inhibitors like Trichostatin A and SAHA enhance Zfp781 activity by promoting histone acetylation, while DNA methyltransferase inhibitors like 5-Azacytidine and Decitabine demethylate regulatory regions, facilitating RNA polymerase II-specific DNA binding. Additionally, compounds like JQ1 and DZNep impact bromodomain proteins and histone methylation, respectively, influencing Zfp781-mediated transcription. These diverse mechanisms collectively contribute to the fine-tuned regulation of gene expression by Zfp781, highlighting its significance in cellular processes requiring precise transcriptional control.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor impacting epigenetic regulation. Potential indirect activator of Zfp781 by inhibiting HDACs, leading to histone acetylation and altered chromatin structure in cis-regulatory regions. Trichostatin A's role involves epigenetic modifications that enhance Zfp781 binding to DNA, promoting transcriptional regulation by RNA polymerase II. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Natural polyphenol affecting multiple signaling pathways. Potential indirect activator of Zfp781 through its anti-inflammatory and epigenetic modulation, influencing the transcriptional regulation by RNA polymerase II. Curcumin's role may involve suppressing inflammatory pathways and modifying chromatin accessibility, enhancing Zfp781 activity in the nucleus. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor impacting gene transcription. Potential indirect activator of Zfp781 by inhibiting bromodomain proteins, altering chromatin structure, and influencing RNA polymerase II activity. JQ1's role involves modulating the epigenetic landscape to facilitate Zfp781 binding to cis-regulatory regions and enhance its transcriptional regulatory function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor influencing DNA methylation. Potential indirect activator of Zfp781 by demethylating cis-regulatory regions, promoting RNA polymerase II-specific DNA binding. 5-Azacytidine's role involves epigenetic modifications that enhance Zfp781's access to regulatory elements, facilitating transcriptional regulation in the nucleus. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
HDAC inhibitor modulating gene expression. Potential indirect activator of Zfp781 by inhibiting HDACs, leading to increased histone acetylation and altered chromatin accessibility for RNA polymerase II. Sodium Butyrate's role involves epigenetic modifications that enhance Zfp781 binding to cis-regulatory regions, promoting its transcriptional regulatory activity in the nucleus. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
PARP inhibitor impacting chromatin structure. Potential indirect activator of Zfp781 through PARP inhibition, influencing RNA polymerase II-mediated transcription. A-485's role involves modulating the chromatin environment to facilitate Zfp781 binding to cis-regulatory regions and enhance its transcriptional regulatory function in the nucleus. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Polyphenolic compound with diverse cellular effects. Potential indirect activator of Zfp781 through its antioxidant and epigenetic modulating properties. Resveratrol's role may involve influencing RNA polymerase II-mediated transcription by altering the chromatin landscape, promoting Zfp781 binding to cis-regulatory regions and enhancing its transcriptional regulatory function in the nucleus. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitor affecting chromatin remodeling. Potential indirect activator of Zfp781 by inhibiting HDACs, promoting histone acetylation, and influencing RNA polymerase II-specific DNA binding. SAHA's role involves epigenetic modifications that enhance Zfp781 binding to cis-regulatory regions, facilitating its transcriptional regulatory function in the nucleus. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Natural triterpenoid impacting multiple pathways. Potential indirect activator of Zfp781 through its anti-inflammatory and epigenetic modulating properties. Betulinic Acid's role involves influencing RNA polymerase II-mediated transcription by modifying chromatin accessibility, promoting Zfp781 binding to cis-regulatory regions and enhancing its transcriptional regulatory function in the nucleus. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor influencing DNA methylation. Potential indirect activator of Zfp781 by demethylating cis-regulatory regions, promoting RNA polymerase II-specific DNA binding. Decitabine's role involves epigenetic modifications that enhance Zfp781's access to regulatory elements, facilitating transcriptional regulation in the nucleus. | ||||||