ZFP28 Inhibitors
Chemical inhibitors of ZFP28 can exert their effects through various intracellular signaling pathways that are crucial for the protein's function. PD168393, an irreversible inhibitor of EGFR tyrosine kinase, disrupts the EGFR pathway, which may be necessary for ZFP28 activity, hence indirectly leading to its inhibition. Similarly, GW5074, which is a potent inhibitor of Raf-1 kinase, and U0126 and PD98059, both selective inhibitors of MEK, can reduce ZFP28 activity by interrupting the MAPK/ERK pathway that ZFP28 may utilize. SB203580's selective inhibition of p38 MAPK could also diminish ZFP28's function if it is related to the p38 MAPK pathway. Additionally, SP600125, by inhibiting the JNK pathway, and Y-27632, by inhibiting ROCK which affects cytoskeleton organization, can suppress ZFP28 function by interfering with other cellular processes and structures that ZFP28 may influence.
Compounds targeting the PI3K/AKT/mTOR pathway also serve as inhibitors of ZFP28, given its potential reliance on this pathway for its functional activity. LY294002 and Wortmannin, both inhibitors of PI3K, along with Triciribine, an AKT inhibitor, can obstruct the upstream signaling that ZFP28 may require, thus leading to its inhibition. Rapamycin, by inhibiting mTOR, can also inhibit ZFP28 by disrupting pathways essential for its activity. Furthermore, Dasatinib, a broad-spectrum tyrosine kinase inhibitor which includes Src family kinases, can functionally inhibit ZFP28 if its activity is regulated through Src kinase signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 168393 | 194423-15-9 | sc-222138 | 1 mg | $162.00 | 4 | |
This chemical is an irreversible inhibitor of EGFR tyrosine kinase. ZFP28 is a zinc finger protein that potentially interacts with EGFR pathway. By inhibiting EGFR, PD168393 disrupts downstream signaling that may be necessary for ZFP28's activity in cells. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a potent inhibitor of Raf-1 kinase. Since the Raf-1 kinase is part of the MAPK/ERK pathway, and ZFP28 may have interactions with this pathway, GW5074's inhibition of Raf-1 can reduce the activity of ZFP28 which relies on this signaling for its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This compound selectively inhibits p38 MAPK. If ZFP28's function is related to the p38 MAPK pathway, inhibiting p38 with SB203580 would diminish ZFP28's ability to act within this pathway, leading to functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By obstructing PI3K, this compound can inhibit the AKT pathway, which is crucial for numerous cellular processes. If ZFP28's function is dependent on this pathway, LY294002 would inhibit ZFP28 by blocking essential upstream signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
This is an inhibitor of c-Jun N-terminal kinase (JNK). JNK is involved in a wide array of cellular activities. Inhibition of JNK by SP600125 can lead to suppression of downstream effectors that would otherwise be necessary for ZFP28 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent inhibitor of PI3K. It functions similarly to LY294002, and if ZFP28 relies on PI3K-driven pathways for its activity, Wortmannin would act as an inhibitor of ZFP28 by obstructing those pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in protein synthesis and cell growth. If ZFP28's function is linked to the mTOR pathway, Rapamycin would inhibit ZFP28 by disrupting the pathway it requires for its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
As a MEK inhibitor, U0126 prevents the activation of MAPK/ERK kinase. If ZFP28 operates within this pathway, the inhibition of MEK by U0126 would lead to a functional inhibition of ZFP28 by blocking necessary upstream signals. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a tyrosine-kinase inhibitor, which could inhibit Src family kinases. If ZFP28's activity is modulated by Src kinase signaling, Dasatinib would functionally inhibit ZFP28 by suppressing this pathway. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor which impacts cytoskeleton organization. If the activity of ZFP28 is tied to cytoskeletal dynamics, then Y-27632 would inhibit ZFP28 by disrupting these necessary cellular structures. | ||||||