ZFHX2 Inhibitors
Inhibitors targeting the functional activity of ZFHX2 operate through various mechanisms that impinge on the signaling pathways and epigenetic modifications regulating its expression and activity. For example, compounds that influence chromatin accessibility and structure, like those that inhibit histone deacetylases, can restrict transcription factor access to DNA, resulting in the diminished expression of ZFHX2. Similarly, agents that interfere with DNA methylation patterns can alter the epigenetic state of the ZFHX2 gene promoter, leading to the suppression of its transcription. Additional inhibitors act by modulating signal transduction pathways, such as the ERK/MAPK and PI3K/AKT pathways, which may regulate ZFHX2 activity. By impeding these pathways, transcription factors including ZFHX2 are less likely to receive activating signals, leading to reduced transcriptional activity.
Moreover, specific inhibitors targeting the Hedgehog, TGF-β, and Notch signaling cascades can indirectly influence the activity of ZFHX2 by altering the expression of genes that are components of these pathways or that are regulated by them. Inhibitors that prevent protein synthesis by targeting mTOR, as well as those that block the cell cycle by inhibiting cyclin-dependent kinases, can also lead to a reduction in ZFHX2 levels and activity. Furthermore, small molecules that obstruct the recruitment of transcriptional coactivators or that inhibit tyrosine kinase receptors involved in growth factor signaling can also modulate ZFHX2 function. For instance, by inhibiting the interaction between BET bromodomain proteins and chromatin, transcriptional regulation of ZFHX2 can be suppressed, while the inhibition of EGFR tyrosine kinase activity can result in attenuated MAPK pathway signaling, potentially impacting ZFHX2's role as a transcription factor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor leads to the alteration of chromatin structure, which can result in the suppression of transcription factors like ZFHX2 by reducing their access to DNA, ultimately leading to decreased expression and activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that reduces DNA methylation, which can downregulate gene expression including ZFHX2 by altering the epigenetic state of its gene promoter, thereby reducing its transcription and activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of MEK1, which then prevents the activation of the ERK/MAPK pathway. Since ZFHX2 is a transcription factor that may be regulated by MAPK signaling, inhibition of this pathway can lead to reduced ZFHX2 function. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
An inhibitor of the Hedgehog signaling pathway by directly targeting Smoothened, which can lead to a decrease in transcription factors regulated by this pathway, potentially including ZFHX2, thereby reducing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A phosphoinositide 3-kinase inhibitor which by blocking PI3K can lead to the downregulation of AKT signaling, potentially affecting transcription factors such as ZFHX2 that may be downstream of this pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A highly selective inhibitor of both MEK1 and MEK2 which could result in the downregulation of transcription factors like ZFHX2 that are potentially regulated by the ERK/MAPK signaling pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor which can lead to the inhibition of downstream protein synthesis and may affect the translation of proteins such as ZFHX2, thus indirectly reducing its functional activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of the TGF-β receptor which can modulate the SMAD signaling pathway. This may lead to reduced activity of transcription factors like ZFHX2 that could be influenced by TGF-β signaling. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
A cyclin-dependent kinase inhibitor that can result in cell cycle arrest, potentially downregulating transcription factors such as ZFHX2 that are involved in cell cycle regulation. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
A gamma-secretase inhibitor that prevents the cleavage of Notch proteins, thereby inhibiting Notch signaling. This can lead to reduced activity of transcription factors like ZFHX2 that may be influenced by Notch pathway. | ||||||