ZFAND2B Inhibitors
ZFAND2B proteasome inhibitors, such as MG132, Bortezomib, Lactacystin, Velcade, Epoxomicin, Carfilzomib, Oprozomib, and Auranofin, affect the proteolytic activity of the proteasome, thus indirectly increasing the levels of ZFAND2B if it is subject to proteasomal degradation. Inhibition of the proteasome can lead to an accumulation of ubiquitinated proteins, which may include ZFAND2B if it is among those targeted for degradation.
Other compounds in this class target upstream components of the UPS. Pyr-41 targets the ubiquitin-activating enzyme E1, preventing the initial step of ubiquitin tagging of proteins. MLN4924 inhibits the NEDD8-activating enzyme, which is essential for the function of ubiquitin ligase enzymes that tag proteins for degradation. VLX1570 and IU1 specifically inhibit deubiquitinating enzymes, which are responsible for removing ubiquitin tags from proteins, thereby regulating the degradation process. By blocking these enzymes, the degradation of ubiquitinated proteins can be affected, which may lead to an increase in ZFAND2B levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that can prevent the degradation of proteins targeted by ubiquitination. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Inhibits the 26S proteasome, leading to an accumulation of proteins marked for degradation. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Specifically inhibits the proteasome, potentially increasing levels of proteins including ZFAND2B. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
A selective proteasome inhibitor, affecting the turnover of ubiquitinated proteins. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $41.00 | ||
An irreversible proteasome inhibitor, impacting protein degradation pathways. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
An irreversible inhibitor of ubiquitin-activating enzyme E1, affecting ubiquitin-dependent protein degradation. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
Inhibits the NEDD8-activating enzyme, which is necessary for the activation of ubiquitin ligases. | ||||||
Oprozomib | 935888-69-0 | sc-477447 | 2.5 mg | $280.00 | ||
An orally bioavailable proteasome inhibitor, affects the degradation pathway of ubiquitinated proteins. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Inhibits the proteasomal deubiquitinases, thus affecting the degradation of ubiquitinated proteins. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
Inhibits the deubiquitinating enzyme USP14, which can modulate proteasome activity. | ||||||