ZFAND2B Antibody (D-2): sc-398000
- ZFAND2B Antibody (D-2) is a mouse monoclonal IgG1 κ ZFAND2B antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 128-149 within an internal region of ZFAND2B of human origin
- ZFAND2B Antibody (D-2) is recommended for detection of ZFAND2B isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- Anti-ZFAND2B Antibody (D-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ZFAND2B Antibody (D-2) for WB applications. These reagents are now offered in bundles with ZFAND2B Antibody (D-2) (see ordering information below).
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ZFAND2B Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZFAND2B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZFAND2B antibody (D-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZFAND2B, also known as AN1-type zinc finger protein 2B, plays a crucial role in the ubiquitination pathway, which is vital for regulating protein degradation and cellular homeostasis. This 257 amino acid protein features two AN1-type zinc fingers and two ubiquitin-interacting motif repeats, allowing ZFAND2B to interact with ubiquitin and other proteins involved in the ubiquitin-proteasome system. The presence of these domains suggests ZFAND2B is involved in the modulation of transcriptional activity and the response to cellular stress, making ZFAND2B an important player in various biological processes, including cell cycle regulation and apoptosis. ZFAND2B is conserved across animals and plants, indicating a fundamental role in cellular functions. Two isoforms of ZFAND2B arise from alternative splicing, which may contribute to functional diversity and regulatory mechanisms within different cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ZFAND2B Antibody (D-2) References:
- Zinc finger peptides for the regulation of gene expression. | Klug, A. 1999. J Mol Biol. 293: 215-8. PMID: 10529348
- Zinc finger proteins: new insights into structural and functional diversity. | Laity, JH., et al. 2001. Curr Opin Struct Biol. 11: 39-46. PMID: 11179890
- Zinc fingers--folds for many occasions. | Matthews, JM. and Sunde, M. 2002. IUBMB Life. 54: 351-5. PMID: 12665246
- ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. | Huang, J., et al. 2004. J Biol Chem. 279: 16847-53. PMID: 14754897
- Zinc finger proteins: getting a grip on RNA. | Brown, RS. 2005. Curr Opin Struct Biol. 15: 94-8. PMID: 15718139
- Multiple modes of RNA recognition by zinc finger proteins. | Hall, TM. 2005. Curr Opin Struct Biol. 15: 367-73. PMID: 15963892
- Sticky fingers: zinc-fingers as protein-recognition motifs. | Gamsjaeger, R., et al. 2007. Trends Biochem Sci. 32: 63-70. PMID: 17210253
- Expression analysis of rice A20/AN1-type zinc finger genes and characterization of ZFP177 that contributes to temperature stress tolerance. | Huang, J., et al. 2008. Gene. 420: 135-44. PMID: 18588956
- Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. | Glinka, T., et al. 2014. Biochem J. 457: 253-61. PMID: 24160817
- Promoter Methylation-Regulated Differentially Expressed Genes in Breast Cancer. | Sindi, S., et al. 2023. Breast Cancer (Dove Med Press). 15: 435-450. PMID: 37434588
- Identification of Missense Variants Affecting Carcass Traits for Hanwoo Precision Breeding. | Lee, DJ., et al. 2023. Genes (Basel). 14: PMID: 37895191
- Two related localized mRNAs from Xenopus laevis encode ubiquitin-like fusion proteins. | Linnen, JM., et al. 1993. Gene. 128: 181-8. PMID: 8390387
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZFAND2B Antibody (D-2) | sc-398000 | 200 µg/ml | $322.00 | |||
ZFAND2B Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-530655 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZFAND2B Antibody (D-2): m-IgGκ BP-HRP Bundle | sc-524175 | 200 µg Ab, 40 µg BP | $361.00 | |||
ZFAND2B Antibody (D-2): m-IgG1 BP-HRP Bundle | sc-544184 | 200 µg Ab; 20 µg BP | $361.00 | |||
ZFAND2B Antibody (D-2) AC | sc-398000 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ZFAND2B Antibody (D-2) HRP | sc-398000 HRP | 200 µg/ml | $322.00 | |||
ZFAND2B Antibody (D-2) FITC | sc-398000 FITC | 200 µg/ml | $336.00 | |||
ZFAND2B Antibody (D-2) PE | sc-398000 PE | 200 µg/ml | $349.00 | |||
ZFAND2B Antibody (D-2) Alexa Fluor® 488 | sc-398000 AF488 | 200 µg/ml | $364.00 | |||
ZFAND2B Antibody (D-2) Alexa Fluor® 546 | sc-398000 AF546 | 200 µg/ml | $364.00 | |||
ZFAND2B Antibody (D-2) Alexa Fluor® 594 | sc-398000 AF594 | 200 µg/ml | $364.00 | |||
ZFAND2B Antibody (D-2) Alexa Fluor® 647 | sc-398000 AF647 | 200 µg/ml | $364.00 | |||
ZFAND2B Antibody (D-2) Alexa Fluor® 680 | sc-398000 AF680 | 200 µg/ml | $364.00 | |||
ZFAND2B Antibody (D-2) Alexa Fluor® 790 | sc-398000 AF790 | 200 µg/ml | $364.00 | |||
ZFAND2B (D-2) Neutralizing Peptide | sc-398000 P | 100 µg/0.5 ml | $69.00 |