ZDHHC19 Inhibitors
ZDHHC19 inhibitors comprise a collection of chemical compounds that directly or indirectly hinder the activity of ZDHHC19, a palmitoyltransferase enzyme. Palmitoyl Coenzyme A, serving as a natural substrate for ZDHHC19, can act as a competitive inhibitor when in excess, limiting ZDHHC19's ability to palmitoylate other proteins. 2-Bromohexadecanoic acid directly inhibits ZDHHC19 by covalently binding to its active site, while Cerulenin and Triacsin C disrupt ZDHHC19 activity by reducing substrate availability, by inhibiting fatty acid synthesis and long-chain acyl-CoA synthetase, respectively. Tunicamycin indirectly modulates ZDHHC19's function by altering glycosylation patterns of potential substrates, and Phenylmethylsulfonyl fluoride may hinder ZDHHC19 by targeting serine-rich regions near its active site. Additionally, 5-Nitro-1H-imidazole-1-ethanol and Curcumin can affect ZDHHC19 through modulation of cellular signaling pathways, such as nitric oxide synthase activity and the PI3K/Akt pathway, impacting protein interactions and substrate recognition.
Moreover, Iodoacetamide targets ZDHHC19 by alkylating its essential cysteine residue, A23187 influences ZDHHC19 by affecting the prenylation of proteins, and PF-429242 diminishes the biosynthesis of lipid substrates necessary for ZDHHC19's activity by inhibiting the serine protease SKI-1/S1P. Lastly, ML348, as an inhibitor of acyl protein thioesterase 1 (APT1), causes an accumulation of palmitoylated proteins, potentially oversaturating ZDHHC19's substrate pool and leading to decreased enzymatic function. Together, these inhibitors employ diverse biochemical mechanisms to attenuate the functional activity of ZDHHC19 by either directly obstructing the enzyme's action or by altering the cellular environment and availability of substrates necessary for its activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Bromohexadecanoic acid | 18263-25-7 | sc-251714 sc-251714A | 10 g 50 g | $53.00 $201.00 | 4 | |
2-Bromohexadecanoic acid is a known inhibitor of protein palmitoylation. By covalently binding to the active site cysteine of palmitoyltransferases like ZDHHC19, it can prevent the enzyme from interacting with its protein substrates, thereby inhibiting its function. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin is a fatty acid synthesis inhibitor that can lead to a reduction in palmitoyl-CoA levels, indirectly diminishing the substrate availability for ZDHHC19's enzymatic activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation. While not directly affecting ZDHHC19, it can alter the glycosylation status of potential substrate proteins, which may impact ZDHHC19's ability to recognize and palmitoylate these substrates. | ||||||
Phenylmethylsulfonyl Fluoride | 329-98-6 | sc-3597 sc-3597A | 1 g 100 g | $50.00 $697.00 | 92 | |
Phenylmethylsulfonyl Fluoride is a serine protease inhibitor that could potentially inhibit serine-rich regions near the active site of ZDHHC19, leading to a decrease in its palmitoyltransferase function. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $255.00 | 1 | |
Iodoacetamide irreversibly inhibits cysteine proteases by alkylating the thiol group of cysteine residues. It could inactivate ZDHHC19 by modifying its active site cysteine that is essential for its palmitoyltransferase activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a farnesyltransferase inhibitor that can decrease the prenylation of proteins, a post-translational modification. By affecting the prenylation status of proteins, it could indirectly affect ZDHHC19's substrate recognition or localization. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to inhibit the PI3K/Akt pathway, which may indirectly decrease the palmitoylation of certain proteins by ZDHHC19 due to altered substrate availability or ZDHHC19 localization. | ||||||
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $187.00 $843.00 | 14 | |
Triacsin C is an inhibitor of long-chain acyl-CoA synthetase, which could lead to a reduction in the levels of acyl-CoAs, including palmitoyl-CoA. This would indirectly decrease the substrate availability for ZDHHC19's activity. | ||||||
PF-429242 | 947303-87-9 | sc-507498 | 5 mg | $176.00 | ||
PF-429242 is a potent inhibitor of the serine protease SKI-1/S1P, which is involved in lipid metabolism. By inhibiting this enzyme, PF-429242 could indirectly decrease the biosynthesis of lipid substrates required for ZDHHC19's enzymatic activity. | ||||||