ZC3H10 Activators
Chemical activators of ZC3H10 operate through various intracellular signaling pathways to modulate its activity, primarily through phosphorylation. Forskolin, by elevating intracellular cAMP levels, triggers the activation of protein kinase A (PKA). Once activated, PKA can phosphorylate ZC3H10, leading to its activation. Similarly, Spermine NONOate releases nitric oxide which stimulates guanylate cyclase, increasing cGMP levels in the cell. The rise in cGMP can activate protein kinase G (PKG), which may then phosphorylate ZC3H10. Ionomycin and A23187, both acting as calcium ionophores, increase the concentration of intracellular calcium, a critical second messenger that activates various calcium-dependent kinases. These kinases, in turn, have the capability to phosphorylate and activate ZC3H10.
Further, the activation of protein kinase C (PKC) by Phorbol 12-myristate 13-acetate (PMA) can lead to the phosphorylation of ZC3H10. Calyculin A and Okadaic Acid prevent the dephosphorylation of proteins by inhibiting protein phosphatases 1 and 2A, which can result in a net increase in phosphorylated proteins, including ZC3H10. Anisomycin, through the activation of the JNK pathway, also targets ZC3H10 for phosphorylation. In addition, Epigallocatechin Gallate (EGCG) activates AMP-activated protein kinase (AMPK), which is known to phosphorylate and activate ZC3H10. Lastly, Zaprinast, by inhibiting phosphodiesterase 5, raises cGMP levels, which can activate PKG that might phosphorylate ZC3H10, thus influencing its activity state. These chemical activators, through different mechanisms, contribute to the regulation of ZC3H10's phosphorylation status and its subsequent activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin functions as a calcium ionophore, increasing intracellular calcium concentrations. The rise in calcium levels activates calcium-dependent kinases that can phosphorylate and activate ZC3H10. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate and activate ZC3H10 by modulating intracellular signaling pathways that ZC3H10 is known to participate in. | ||||||
Spermine NONOate | 136587-13-8 | sc-202816 sc-202816A | 5 mg 25 mg | $53.00 $196.00 | 5 | |
Spermine NONOate releases nitric oxide, which activates guanylate cyclase to increase cGMP levels. Elevated cGMP can activate PKG, which may phosphorylate and activate ZC3H10. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore like ionomycin, raising intracellular calcium levels and potentially activating calcium-dependent kinases that could phosphorylate and activate ZC3H10. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation levels within the cell. This can indirectly lead to the activation of ZC3H10 through enhanced phosphorylation states of proteins within its signaling pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid, similarly to Calyculin A, inhibits protein phosphatases, which could result in the phosphorylation and subsequent activation of ZC3H10 by maintaining it in a phosphorylated state. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates the stress-activated protein kinase/JNK pathway. JNK can phosphorylate and activate ZC3H10 as part of its downstream effectors. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, which may lead to compensatory activation of alternative kinases capable of phosphorylating and activating ZC3H10. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates AMP-activated protein kinase (AMPK), which can phosphorylate and activate ZC3H10 as part of its downstream signaling effects. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits phosphodiesterase 5, thus raising cGMP levels and potentially activating PKG, which could then phosphorylate and activate ZC3H10. | ||||||