ZBTB6 Activators
The chemical class of ZBTB6 activators encompasses a variety of compounds found in natural sources such as plants. These activators exert their effects by targeting specific signaling pathways implicated in the regulation of ZBTB6 expression and activity.
Many of these activators, such as curcumin, parthenolide, and resveratrol, function by inhibiting the NF-κB signaling pathway. They prevent the phosphorylation and subsequent degradation of IκBα, thereby blocking the nuclear translocation of NF-κB and promoting the transcription of ZBTB6. Other activators, like withaferin A and gambogic acid, target the JAK/STAT signaling pathway. They suppress the phosphorylation of STAT3, leading to the inhibition of STAT3-mediated transcriptional activity and subsequent upregulation of ZBTB6 expression. Additionally, compounds such as emodin and baicalein activate ZBTB6 by modulating the Wnt/β-catenin signaling pathway. They inhibit the nuclear translocation of β-catenin, resulting in the downregulation of TCF/LEF-mediated transcription and enhancement of ZBTB6 expression. Overall, these ZBTB6 activators represent a diverse group of compounds that hold potential for modulating ZBTB6 expression and function through targeted manipulation of specific signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide, a bioactive compound extracted from Andrographis paniculata, activates ZBTB6 by modulating the NF-κB signaling pathway. It inhibits the degradation of IκBα, leading to the nuclear translocation of NF-κB and subsequent upregulation of ZBTB6 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound found in turmeric, activates ZBTB6 by inhibiting NF-κB activation. It suppresses the phosphorylation and degradation of IκBα, thereby preventing the nuclear translocation of NF-κB and promoting the transcription of ZBTB6. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $75.00 $221.00 | 6 | |
Carnosic acid, a phenolic diterpene present in rosemary, activates ZBTB6 by modulating the MAPK signaling pathway. It inhibits the phosphorylation of ERK and JNK, leading to the downregulation of AP-1 activity and subsequent enhancement of ZBTB6 expression. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol, a triterpenoid compound derived from Tripterygium wilfordii, activates ZBTB6 by inhibiting the PI3K/Akt signaling pathway. It suppresses the phosphorylation of Akt, resulting in the inhibition of mTOR activity and subsequent upregulation of ZBTB6 expression. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Emodin, a natural anthraquinone derivative found in various plants, activates ZBTB6 by inhibiting the Wnt/β-catenin signaling pathway. It suppresses the nuclear translocation of β-catenin, leading to the downregulation of TCF/LEF-mediated transcription and enhancement of ZBTB6 expression. | ||||||
Gambogic Acid | 2752-65-0 | sc-200137 sc-200137A sc-200137B sc-200137C sc-200137D | 5 mg 25 mg 100 mg 500 mg 1 g | $87.00 $248.00 $427.00 $734.00 $1255.00 | 5 | |
Gambogic acid, a natural product isolated from Garcinia hanburyi, activates ZBTB6 by modulating the JAK/STAT signaling pathway. It inhibits the phosphorylation of STAT3, leading to the suppression of STAT3-mediated transcriptional activity and subsequent upregulation of ZBTB6 expression. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein, a flavonoid found in Scutellaria baicalensis, activates ZBTB6 by inhibiting the NF-κB signaling pathway. It prevents the phosphorylation and degradation of IκBα, thereby inhibiting the nuclear translocation of NF-κB and promoting the transcription of ZBTB6. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A, a steroidal lactone present in Withania somnifera, activates ZBTB6 by inhibiting the STAT3 signaling pathway. It suppresses the phosphorylation of STAT3, leading to the inhibition of STAT3-mediated transcription and subsequent upregulation of ZBTB6 expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide, a sesquiterpene lactone derived from feverfew, activates ZBTB6 by inhibiting the NF-κB signaling pathway. It blocks the phosphorylation and degradation of IκBα, preventing the nuclear translocation of NF-κB and promoting the transcription of ZBTB6. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol found in grapes and red wine, activates ZBTB6 by inhibiting the NF-κB signaling pathway. It suppresses the phosphorylation and degradation of IκBα, thereby preventing the nuclear translocation of NF-κB and promoting the transcription of ZBTB6. | ||||||