ZBTB48 Inhibitors
ZBTB48 inhibitors consist of diverse chemical compounds that attenuate the functional activity of ZBTB48 through various specific biochemical pathways. Trichostatin A and Suberoylanilide Hydroxamic Acid are histone deacetylase inhibitors that enhance histone acetylation, which can lead to transcriptional repression of certain genes; this modifies chromatin structure in a way that may reduce ZBTB48's DNA binding affinity, thus hindering its transcriptional regulatory function. Mithramycin A, by intercalating into DNA, potentially obstructs ZBTB48's access to GC-rich DNA sequences, its typical binding targets. Chemicals that alter cellular compartments and degradation pathways, such as Chloroquine and the proteasome inhibitor MG-132, can affect ZBTB48 by disrupting the degradation of proteins that regulate its activity or stability. Cycloheximide's inhibition of protein synthesis can reduce the levels of proteins essential for ZBTB48 function, while Epigallocatechin Gallate and 5-Azacytidine affect DNA methylation patterns and could alter the gene expression landscape regulated by ZBTB48.
Further impacting ZBTB48's role, Retinoic acid may compete with ZBTB48 for binding to specific DNA sequences, thereby decreasing its regulatory influence. PD 98059 and LY 294002 target key cell signaling pathways, namely MEK/ERK and PI3K/AKT, potentially affecting the phosphorylation state and, consequently, the activity of ZBTB48 or its associated regulatory proteins. Lastly, Rapamycin inhibits mTOR signaling, a pathway integral to cell growth and proliferation, which can lead to altered expression or function of transcription factors such as ZBTB48. These inhibitors, by interacting with different aspects of cellular regulation, contribute to the diminished activity of ZBTB48.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that increases acetylation of histones, leading to transcriptional repression. ZBTB48 is a transcription factor that can be inhibited by such epigenetic modifications, decreasing its DNA binding affinity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Histone deacetylase inhibitor, promoting histone acetylation and potentially diminishing ZBTB48's ability to regulate gene expression by altering chromatin structure. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
DNA-binding compound that intercalates into GC-rich sequences, potentially inhibiting ZBTB48 from binding to its target DNA sequences. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Raises endosomal pH and can interfere with lysosomal degradation pathways. This can lead to the accumulation of misfolded proteins, potentially diminishing ZBTB48's functional stability. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that prevents the degradation of ubiquitinated proteins, possibly leading to the reduced activity of ZBTB48 through the accumulation of regulatory proteins that inhibit its function. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Protein synthesis inhibitor that can indirectly lead to the diminished function of ZBTB48 by reducing the synthesis of proteins necessary for its function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Catechin found in green tea with antioxidant properties, known to inhibit DNA methyltransferases, potentially influencing the methylation status of genes regulated by ZBTB48 and thus its activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor that may reduce the methylation of DNA, altering the expression of genes that interact with or are regulated by ZBTB48, leading to its functional inhibition. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Metabolite of vitamin A that regulates gene expression through retinoic acid receptors, which may compete with ZBTB48 for DNA binding sites, diminishing its regulatory function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that blocks the MAPK/ERK pathway, potentially altering the phosphorylation state of proteins that regulate ZBTB48's activity or its target genes. | ||||||