ZBED2 Activators
Common ZBED2 Activators include, but are not limited to Forskolin CAS 66575-29-9, IBMX CAS 28822-58-4, PMA CAS 16561-29-8, Ionomycin free acid CAS 56092-81-0 and LY 294002 CAS 154447-36-6.
ZBED2, Zinc finger BED domain-containing protein 2, is a transcriptional regulator involved in the modulation of gene expression and chromatin remodeling. It functions primarily as a transcriptional repressor, exerting regulatory control over target genes through interactions with DNA and other protein partners. ZBED2 contains multiple zinc finger domains that enable it to bind specifically to DNA sequences within the genome, thereby influencing the transcriptional activity of nearby genes. Additionally, ZBED2 interacts with various chromatin-modifying enzymes and transcriptional regulators to modulate the accessibility of DNA and the organization of chromatin structure. Through these interactions, ZBED2 plays a crucial role in regulating diverse cellular processes, including cell proliferation, differentiation, and development.
Activation of ZBED2 involves intricate molecular mechanisms that modulate its transcriptional repressor activity and influence its interaction with DNA and chromatin. One mechanism of activation entails post-translational modifications, such as phosphorylation, acetylation, or methylation, which can alter ZBED2's conformation, stability, or DNA-binding affinity. These modifications may occur in response to specific cellular signals or environmental cues, leading to the activation of ZBED2-mediated gene regulatory pathways. Additionally, activation may occur through the binding of specific protein cofactors or transcriptional regulators that modulate ZBED2's activity. These cofactors can either enhance or attenuate ZBED2's repressive function, depending on the context of gene expression regulation. Furthermore, activation of signaling pathways or cellular stress responses can indirectly influence ZBED2 activity by altering the expression or activity of its regulatory partners. Overall, activation of ZBED2 orchestrates complex transcriptional programs that govern cellular phenotypes and contribute to the regulation of diverse biological processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene that activates adenylate cyclase, leading to increased cAMP levels in cells. As cAMP is a second messenger that can activate protein kinase A (PKA), it indirectly enhances the activity of ZBED2 by potentially phosphorylating substrates or regulatory proteins that control ZBED2's function in the cell. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, which prevents cAMP degradation, thereby sustaining the activation of cAMP-dependent pathways. This prolonged activation can indirectly enhance ZBED2 activity through cAMP-responsive elements that may be part of ZBED2's regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to downstream effects that indirectly increase the activity of ZBED2 through signaling pathways that intersect with ZBED2's regulatory functions. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-sensitive signaling pathways. Enhanced calcium signaling may indirectly promote ZBED2 activity by influencing cellular processes or regulatory proteins that modulate ZBED2 function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which indirectly might enhance ZBED2 activity by modulating the MAPK/ERK pathway and shifting the balance of signaling towards pathways that upregulate or activate ZBED2. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell. This hyperphosphorylated state could enhance ZBED2 activity by affecting proteins that regulate ZBED2 function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that can increase intracellular calcium and activate calcium-dependent signaling pathways. This increased calcium signaling can indirectly enhance ZBED2 activity by modulating cellular processes that ZBED2 may be involved in. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is a polyamine that has been implicated in the stabilization of DNA-binding proteins and chromatin structure. It may indirectly enhance ZBED2 activity by affecting its DNA-binding capacity or the accessibility of its target genomic regions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol found in green tea that has been shown to inhibit multiple kinases. This broad inhibition of kinase activity may indirectly enhance ZBED2 activity by affecting signaling pathways that intersect with ZBED2's function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can modulate the activity of proteins involved in cell growth and survival. By inhibiting mTOR, rapamycin may indirectly enhance ZBED2 activity by influencing signaling pathways that regulate ZBED2's function or expression. | ||||||