Zap3 Activators
Zap3 activators function through a variety of biochemical mechanisms that lead to its enhanced activity. Certain activators work by directly stimulating adenylyl cyclase, thereby increasing intracellular levels of cAMP, a secondary messenger that activates protein kinase A (PKA). PKA, in turn, can phosphorylate Zap3, thereby increasing its activity. Other activators operate through G protein-coupled receptor signaling cascades initiated by agonists that lead to elevated cAMP levels and subsequent PKA activation, which also targets Zap3 for activation through phosphorylation. Additionally, some activators bypass traditional receptor-mediated pathways and directly elevate intracellular calcium levels, which activates calcium-dependent protein kinases that are capable of phosphorylating and activating Zap3.
Furthermore, the inhibition of phosphodiesterases represents another mechanism by which activators can increase Zap3 activity. By preventing the breakdown of cAMP, these inhibitors lead to sustained PKA signaling and potential phosphorylation of Zap3. There are also compounds that inhibit serine/threonine phosphatases, leading to an accumulation of phosphorylated proteins, including Zap3, thus maintaining it in an active state. Other activators modulate the phosphorylation state of proteins within Zap3's signaling pathway, indirectly enhancing its activity. Stress-activated protein kinase pathways, when triggered, may also lead to the phosphorylation and consequent activation of Zap3.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
This compound directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. The elevated cAMP activates PKA, which can phosphorylate Zap3, enhancing its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A β-adrenergic agonist that binds to receptors, triggering a G protein-coupled receptor signaling cascade. This results in increased cAMP and activation of PKA, which then can lead to the phosphorylation and activation of Zap3. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which may lead to the phosphorylation of downstream targets that modulate Zap3 activity through phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that raises intracellular calcium levels, potentially activating calcium-dependent protein kinases, which could then phosphorylate and activate Zap3. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, preventing cAMP breakdown, which leads to PKA activation and could enhance Zap3 phosphorylation and activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that increases intracellular calcium concentration, activating calcium/calmodulin-dependent protein kinases that can phosphorylate and modulate Zap3 activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective inhibitor of phosphodiesterase 4, which elevates intracellular cAMP levels, leading to PKA activation and potential phosphorylation of Zap3. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
An inhibitor of protein tyrosine kinases that can indirectly increase the activity of Zap3 by modulating the phosphorylation state of proteins in its signaling pathway. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
A serine/threonine phosphatase inhibitor that may lead to increased phosphorylation levels of Zap3 by preventing its dephosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 and 2A, which prevents dephosphorylation of proteins, potentially maintaining Zap3 in an activated phosphorylated state. | ||||||