XAGE-1 Activators
XAGE-1, standing for X Antigen family member G1, is a protein encoded by the XAGE-1 gene, which is part of a broader family of XAGE genes. These genes are categorized as cancer-testis antigens (CTAs), a class of tumor-associated antigens with normal expression largely restricted to the testis, an immune-privileged site, and aberrantly activated in various cancers. XAGE-1 expression is particularly noted in Ewing's sarcoma, lung, breast, prostate, and other solid tumors.
The biological function of XAGE-1 is not fully elucidated, but it is thought to be involved in the regulation of gene expression and possibly in the immune response to cancer cells. Its restricted expression pattern makes it an attractive target for cancer immunotherapy, as it may be recognized by the immune system as a foreign antigen when expressed in tumors, allowing for the development of XAGE-1-targeted vaccines or adoptive T-cell therapies.The aberrant expression of XAGE-1 in tumors is believed to be due to dysregulated epigenetic mechanisms that normally silence CTAs in non-germline tissues. The presence of XAGE-1 in tumors can sometimes elicit a spontaneous immune response, and its detection can serve as a biomarker for certain types of cancer.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methyltransferase inhibitor that may demethylate the XAGE-1 promoter, leading to gene re-expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An HDAC inhibitor that could increase histone acetylation and activate XAGE-1 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another HDAC inhibitor that may enhance histone acetylation and promote XAGE-1 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase inhibitor that can induce hyperacetylation of histones and potentially increase XAGE-1 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
An isoflavone that may act as an epigenetic modulator, possibly affecting XAGE-1 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known to have epigenetic modulatory effects that could lead to changes in XAGE-1 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
May modulate epigenetic marks and influence XAGE-1 expression in cancer cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Can affect histone deacetylases and potentially induce the expression of tumor antigens like XAGE-1. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Has been shown to inhibit DNA methyltransferases, which could lead to the re-expression of genes like XAGE-1. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
May alter epigenetic states, thus potentially inducing XAGE-1 expression. | ||||||