WTX Inhibitors
WTX inhibitors as a chemical class refer to compounds that can indirectly influence the function of WTX by targeting various points in the Wnt/β-catenin pathway, which WTX is known to affect. These compounds can destabilize the β-catenin complex, inhibit coactivators, stop the secretion of Wnt ligands, or disrupt downstream signaling, which in turn may lead to modulation of WTX activity within the cell. XAV-939, ICG-001, LGK-974, and JW55 function by disrupting the normal signaling cascade that WTX is a part of, which may result in the downregulation of WTX-related cellular processes.
Continuing, compounds like FH535, KY02111, PKF118-310, CGP049090, CCT036477, PNU-74654, WIKI4, and IWR-1 serve to alter the Wnt/β-catenin pathway at different stages, from ligand secretion to coactivator binding to transcriptional regulation. By inhibiting these points in the pathway, they can effectively decrease the signaling that is necessary for WTX to exert its effects on the cell. This disruption can result in changes to the cellular environment and processes that WTX influences. These inhibitors offer a means to modulate WTX activity by altering the surrounding signaling pathways, thereby indirectly affecting the role of WTX in cellular functions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Tankyrase inhibitor that stabilizes Axin by preventing its poly-ADP-ribosylation, leading to β-catenin degradation and potential downregulation of WTX-influenced pathways. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
Inhibits the Porcupine enzyme, which is necessary for Wnt ligand secretion and thus can decrease Wnt signaling activity involving WTX. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
Inhibits the interaction between β-catenin and its coactivators, possibly reducing WTX-related signaling. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
Inhibits both Wnt/β-catenin signaling and PPAR signaling, potentially altering WTX-related cellular processes. | ||||||
CCT128930 | 885499-61-6 | sc-364459 sc-364459A | 5 mg 10 mg | $156.00 $292.00 | 2 | |
TCF/β-catenin complex inhibitor that can decrease Wnt signaling transcription, affecting WTX-related mechanisms. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
Inhibits the Wnt signaling pathway downstream, potentially impacting the cellular processes WTX is involved in. | ||||||
Akt Inhibitor IV | 681281-88-9 | sc-203809 sc-203809A | 5 mg 25 mg | $176.00 $709.00 | 42 | |
Inhibits Wnt/β-catenin signaling pathway at the level of the β-catenin/TCF interaction, potentially affecting WTX function. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
Stabilizes Axin and promotes the degradation of β-catenin, leading to potential downregulation of WTX-associated signaling. | ||||||