Molecular structure of CCT128930, CAS Number: 885499-61-6
CCT128930 (CAS 885499-61-6)
See product citations (2)
Alternate Names:
4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine
Application:
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2
CAS Number:
885499-61-6
Purity:
≥98%
Molecular Weight:
341.84
Molecular Formula:
C18H20ClN5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 (IC50: 6 nM). CCT128930 may act to exhibit marked antiproliferative activity against PTEN-deficient human tumor cell lines including U87MG human glioblastoma cells, LNCaP human prostate cancer cells and PC3 human prostate cancer cells (GI50′s: U87MG = 6.3 muM, LNCaP = 0.35 mumol/L and PC3 = 1.9 mumol/L). Furthermore, CCT128930 causes a G1 arrest in PTEN-null U87MG human glioblastoma cells and Akt pathway blockade.
CCT128930 (CAS 885499-61-6) References
- Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. | Yap, TA., et al. 2011. Mol Cancer Ther. 10: 360-71. PMID: 21191045
- CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. | Wang, FZ., et al. 2014. Biochimie. 103: 118-25. PMID: 24793486
- Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors. | Fang, Z., et al. 2015. ACS Chem Biol. 10: 279-88. PMID: 24959717
- Epigenetic changes of EGFR have an important role in BRAF inhibitor-resistant cutaneous melanomas. | Wang, J., et al. 2015. J Invest Dermatol. 135: 532-541. PMID: 25243790
- Inhibition of Phospho-S6 Kinase, a Protein Involved in the Compensatory Adaptive Response, Increases the Efficacy of Paclitaxel in Reducing the Viability of Matrix-Attached Ovarian Cancer Cells. | Choi, JI., et al. 2016. PLoS One. 11: e0155052. PMID: 27148873
- High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway. | Chen, O., et al. 2017. Sci Rep. 7: 14871. PMID: 29093541
- Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms. | Bjune, K., et al. 2019. PLoS One. 14: e0218537. PMID: 31216345
- Neutrophils homing into the retina trigger pathology in early age-related macular degeneration. | Ghosh, S., et al. 2019. Commun Biol. 2: 348. PMID: 31552301
- Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma. | Kim, KW., et al. 2019. Oncotarget. 10: 5645-5659. PMID: 31608140
- CCT128930 induces G1-phase arrest and apoptosis and synergistically enhances the anticancer efficiency of VS5584 in human osteosarcoma cells. | Sun, JY., et al. 2020. Biomed Pharmacother. 130: 110544. PMID: 32721630
- Corrigendum to 'CCT128930 induces G1-phase arrest and apoptosis and synergistically enhances the anticancer efficiency of VS5584 in human osteosarcoma cells' [Biomed. Pharmacother. 130 (2020) 110544]. | Sun, JY., et al. 2020. Biomed Pharmacother. 132: 110931. PMID: 33254436
- CCT128930 is a novel and potent antagonist of TRPM7 channel. | Guan, Z., et al. 2021. Biochem Biophys Res Commun. 560: 132-138. PMID: 33989904
- Modulators of TRPM7 and its potential as a drug target for brain tumours. | Ji, D., et al. 2022. Cell Calcium. 101: 102521. PMID: 34953296
- Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes. | Qiu, R., et al. 2022. Mol Metab. 66: 101644. PMID: 36436807
- PM2.5 induces cardiac malformations via PI3K/akt2/mTORC1 signaling pathway in zebrafish larvae. | Jiang, Y., et al. 2023. Environ Pollut. 323: 121306. PMID: 36804889
Inhibitor of:
Akt2, ARHGEF3, C1orf80, CCDC22, GRAMD4, MOB3A, Olfr553, OXSR1, PKC λ/ι, RGL2, Ser/Thr Protein Kinase, and WTX.Activator of:
ARP-1, LOC727954, Pygopus 2, and STI1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCT128930, 5 mg | sc-364459 | 5 mg | $153.00 | |||
CCT128930, 10 mg | sc-364459A | 10 mg | $286.00 |