WFDC17 Activators
WFDC17, also known as WAP four-disulfide core domain 17, is a protein involved in various cellular processes, including immune response regulation and host defense. It plays a crucial role in maintaining homeostasis in the respiratory and gastrointestinal tracts by inhibiting proteolytic enzymes and protecting against microbial invasion. The activation of WFDC17 is essential for its ability to modulate immune responses and protect against infections. The activation mechanisms of WFDC17 involve various pathways, including the cAMP-PKA pathway through Forskolin, SIRT1 activation through Resveratrol, and PKC activation via PMA. Additionally, A23187 triggers calcium-dependent kinases, while Sodium Orthovanadate inhibits protein tyrosine phosphatases to activate WFDC17. Rolipram inhibits PDE4, increasing cAMP levels and subsequently activating WFDC17.
Furthermore, Bay K 8644 enhances calcium channel activity, Lithium Chloride stabilizes WFDC17 through the Wnt/β-catenin pathway, and Calcitriol boosts WFDC17 expression via the vitamin D receptor. Chlorogenic Acid modulates WFDC17 through the NF-κB pathway, and Ionomycin induces calcium influx, leading to WFDC17 activation. These chemicals offer a diverse array of activation mechanisms, providing valuable insights into potential strategies for controlling WFDC17 function in various physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates WFDC17 by stimulating adenylate cyclase, leading to an increase in intracellular cAMP levels. This elevation in cAMP subsequently activates protein kinase A (PKA), which directly phosphorylates and activates WFDC17. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates WFDC17 through the activation of SIRT1, a NAD+-dependent deacetylase. SIRT1 deacetylates and activates WFDC17, enhancing its function in various cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates WFDC17 by stimulating protein kinase C (PKC), which leads to the phosphorylation and subsequent activation of WFDC17. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 activates WFDC17 by promoting calcium influx into cells, which activates calcium-dependent kinases that phosphorylate and activate WFDC17. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium Orthovanadate activates WFDC17 by inhibiting protein tyrosine phosphatases (PTPs), allowing sustained phosphorylation and activation of WFDC17 through tyrosine kinases. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram activates WFDC17 by inhibiting phosphodiesterase 4 (PDE4), leading to increased cAMP levels and subsequent activation of protein kinase A (PKA), which activates WFDC17. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644 activates WFDC17 by enhancing calcium channel activity, increasing intracellular calcium levels, and triggering calcium-dependent kinases that activate WFDC17. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates WFDC17 by inhibiting GSK-3β, leading to the stabilization and activation of WFDC17 through the Wnt/β-catenin signaling pathway. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
Calcitriol activates WFDC17 by binding to the vitamin D receptor (VDR), which translocates to the nucleus and enhances WFDC17 gene transcription, ultimately increasing its activity. | ||||||
Chlorogenic Acid | 327-97-9 | sc-204683 sc-204683A | 500 mg 1 g | $46.00 $68.00 | 1 | |
Chlorogenic Acid activates WFDC17 by modulating the NF-κB signaling pathway, which directly regulates WFDC17 expression and activity in response to inflammatory stimuli. | ||||||