WDR68 Activators
WDR68 Activators encompass a variety of chemical compounds that serve to amplify the functional activity of WDR68 through discrete signaling pathways and cellular processes. Forskolin and Rolipram, by increasing cAMP levels, activate protein kinase A (PKA), which is known to phosphorylate substrates that could interact with WDR68, thus enhancing its signal transduction capabilities. The activation of PKA by these compounds indirectly potentiates the function of WDR68 in various cellular contexts. Similarly, Retinoic acid, acting through retinoic acid receptors, can induce transcriptional changes that would favor the activity of WDR68, particularly in developmental signaling processes. Lithium, through the inhibition of GSK-3, indirectly promotes the activity of WDR68 by stabilizing β-catenin in the Wnt signaling pathway. Resveratrol activates SIRT1, which in turn can modulate pathways involving WDR68, leading to its enhanced function.
Moreover, U0126 and PD98059 induce alterations in their respective pathways, the effects of which can cascade to affect WDR68 activity,resulting in an enhanced functional state. Trichostatin A, by affecting histone deacetylation, may alter gene expression patterns that are crucial for the pathways where WDR68 is a key player, leading to an upregulation of its activity without directly interacting with the protein. These chemical activators, by targeting specific kinases or signaling molecules, create a more conducive environment for the functional enhancement of WDR68.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly elevates intracellular cAMP levels, which in turn activates PKA. PKA phosphorylates various substrates that can interact with WDR68, enhancing its role in signal transduction processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts through its nuclear receptors which can initiate transcriptional changes influencing the WDR68 pathway, thus indirectly increasing the functional activity of WDR68 in developmental signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to affect numerous signaling pathways including those that involve WDR68, such as NF-κB pathway. By modulating this pathway, curcumin can enhance the activity of WDR68. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4) leading to increased cAMP levels which can enhance PKA activity and subsequently influence the function of WDR68. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit GSK-3, which can lead to the stabilization and accumulation of β-catenin, a molecule that interacts with WDR68 in Wnt signaling pathways, thereby enhancing WDR68 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences SIRT1 activation, which affects multiple cellular pathways including ones associated with WDR68. This can lead to enhanced functional activity of WDR68. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
This compound is a PKC activator which can modulate pathways involving WDR68, leading to enhanced signaling related to its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit several protein kinases, potentially leading to the activation of pathways in which WDR68 is involved, thus indirectly enhancing the activity of WDR68. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor which can lead to alterations in downstream signaling pathways involving WDR68, resulting in the enhancement of its activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor that can alter MAPK signaling. These alterations can indirectly enhance the activity of WDR68 by affecting its signaling pathways. | ||||||