WDR63 Inhibitors
WDR63 inhibitors encompass a range of chemical compounds that interact with cellular signaling pathways to decrease the functional activity of WDR63, a protein potentially involved in various biological processes. Staurosporine, known for its broad kinase inhibition, may interfere with kinase-mediated phosphorylation necessary for WDR63 function, while LY294002 and Wortmannin, both PI3K inhibitors, could obstruct PI3K-dependent pathways that regulate WDR63's post-translational modifications or stability. Rapamycin, targeting the mTOR pathway, may indirectly impact WDR63's role in cell growth or proliferation, given that these cellular processes might be under the governance of mTOR. Cycloheximide and MG132 operate at the level of protein synthesis and degradation, respectively; the former blocks the synthesis of WDR63, while the latter may disrupt its turnover by inhibiting proteasome function, which could affect WDR63 if itis subject to ubiquitin-mediated degradation.
In the second paragraph, the focus shifts to other specific inhibitors and their potential interactions with WDR63. SB203580 and PD98059, by inhibiting p38 MAPK and MEK, may suppress WDR63 activity if it is associated with these MAPK pathway components. U0126, another MEK1/2 inhibitor, reinforces this pathway-specific inhibition, suggesting an indirect downregulation of WDR63 activity if it is downstream of or regulated by ERK1/2. Brefeldin A disrupts protein trafficking from the ER to the Golgi, potentially affecting WDR63 if it plays a role in vesicular transport processes. Additionally, SP600125's inhibition of JNK signaling could interfere with WDR63's function in stress response pathways, while NF449, by selectively inhibiting Gs-alpha, might impede any G-protein-coupled receptor pathways interacting with WDR63, leading to decreased activity of the protein. Collectively, these inhibitors target a variety of pathways, suggesting that WDR63's function is multifaceted and could be influenced by numerous cellular processes.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. WDR63 is a WD-repeat protein that may be involved in cell cycle control and signal transduction pathways. Staurosporine's broad activity may result in the inhibition of kinase interactions or phosphorylation events required for WDR63 function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, LY294002 may impair downstream signaling that could be essential for the regulation or stability of WDR63 through post-translational modifications or interactions with PI3K-dependent pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of the mTOR pathway, which is involved in cell growth and proliferation. Inhibition of mTOR could alter the cellular context in which WDR63 operates, thereby indirectly affecting its function, particularly if WDR63 is involved in processes linked to growth or proliferation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein biosynthesis by interfering with the translocation step in protein synthesis on ribosomes. While not directly targeting WDR63, it can indirectly lead to decreased levels of WDR63 by preventing its synthesis. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to accumulation of polyubiquitinated proteins. If WDR63 is regulated by ubiquitination, inhibiting the proteasome may result in disrupted turnover and function of WDR63. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. If WDR63 is involved in p38 MAPK-dependent signaling pathways, this compound could inhibit those pathways and indirectly decrease the functional activity of WDR63. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK1/2 in the MAPK pathway. If WDR63 functions downstream of or is regulated by the MAPK pathway, U0126 could indirectly decrease its activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus. If WDR63 is involved in protein trafficking, this inhibition could disrupt its localization and function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which might indirectly inhibit the functional activity of WDR63 if it is involved in the MEK/ERK pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K, which might lead to the inhibition of WDR63 activity if WDR63 is involved in PI3K-mediated signaling pathways. | ||||||