WDR51B Inhibitors
Chemical inhibitors of WDR51B can disrupt its role in various stages of cell division by targeting specific proteins involved in the cell cycle and mitosis. Palbociclib, Roscovitine, Dinaciclib, and Purvalanol A inhibit cyclin-dependent kinases (CDKs) such as CDK1, CDK2, CDK4, and CDK6, which are vital for the progression of the cell cycle. By inhibiting these kinases, these chemicals block the phosphorylation of proteins like the retinoblastoma (Rb) protein, leading to cell cycle arrest. Since WDR51B is implicated in cell division, particularly in centriole duplication, its function is inhibited as a consequence of the cell cycle arrest. Similarly, Nocodazole and Taxol target microtubules, which are structural components essential for mitotic spindle function. Nocodazole disrupts microtubule polymerization, while Taxol stabilizes microtubules to such an extent that it prevents their dynamic instability, both leading to the inhibition of WDR51B's role in spindle assembly and centrosome separation.
In addition to targeting the cell cycle, other chemical inhibitors affect mitotic kinases and proteins involved in spindle assembly. BI 2536 and Alisertib inhibit polo-like kinase 1 (PLK1) and Aurora A kinase, respectively, both of which are crucial for mitosis. The inhibition of PLK1 and Aurora A kinase results in mitotic arrest and disruption of centrosome maturation and separation, processes in which WDR51B has functional roles. S-Trityl-L-cysteine and Monastrol are specific inhibitors of the mitotic kinesin Eg5, leading to spindle bipolarity defects, which also functionally inhibit WDR51B. Moreover, ZM447439, an inhibitor of Aurora kinases, compromises spindle assembly and cytokinesis, further inhibiting WDR51B's role in these processes. Mardepodect, which inhibits the microtubule depolymerizing kinesin MCAK, affects chromosome segregation and spindle dynamics, implicating the functional inhibition of WDR51B in these mitotic events. Collectively, these chemical inhibitors can directly or indirectly disrupt the functional role of WDR51B in cell cycle progression and mitosis by targeting various proteins and processes essential for cell division.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib selectively inhibits CDK4/6, which are crucial for cell cycle progression. Inhibition of CDK4/6 can decrease the phosphorylation of the retinoblastoma (Rb) protein, leading to cell cycle arrest. Since WDR51B is implicated in cell division, particularly centriole duplication, cell cycle arrest would inhibit the functional role of WDR51B in this process. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine selectively inhibits CDKs, including CDK2, which is involved in cell cycle regulation. By inhibiting CDK2, the cell cycle is halted, and this cessation can impede the function of WDR51B, which is associated with cell cycle-dependent centriole biogenesis. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $242.00 $871.00 | 1 | |
Dinaciclib is a potent CDK inhibitor, particularly affecting CDK2, CDK5, CDK1, and CDK9. Its inhibition of CDK1 can block the cell cycle progression at the G2/M transition, a critical phase where WDR51B is known to function in centriole duplication and spindle formation. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
BI 2536 is a PLK1 inhibitor. PLK1 plays a pivotal role in mitosis and the inhibition would result in mitotic arrest. WDR51B's function in centrosome integrity and spindle assembly would be inhibited as a consequence of mitotic arrest induced by BI 2536. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
S-Trityl-L-cysteine is a specific inhibitor of the mitotic kinesin Eg5 which is essential for spindle bipolarity. WDR51B would be functionally inhibited as spindle assembly and centrosome cohesion are disrupted, which are processes where WDR51B is involved. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is another Eg5 kinesin inhibitor. By inhibiting Eg5, it leads to the formation of monopolar spindles, which would functionally inhibit WDR51B's role in bipolar spindle assembly during mitosis. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor. Aurora kinases are essential for chromosome alignment and segregation, and their inhibition would compromise spindle assembly and cytokinesis where WDR51B is functionally implicated. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization. As microtubule dynamics are critical for mitosis, this disruption would inhibit WDR51B's function in centrosome separation and spindle assembly. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules and prevents their disassembly, which is essential for proper mitotic spindle function. Overstabilization by Taxol would paradoxically inhibit spindle dynamics and in turn inhibit WDR51B's function in spindle formation. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a potent inhibitor of CDKs, including CDK1 and CDK2. Its inhibition of these kinases leads to a block in cell cycle progression, thereby inhibiting the function of WDR51B in cell cycle-dependent processes like centriole duplication. | ||||||