WDR24 Activators
WDR24 activators are a collection of chemical compounds that serve to indirectly enhance the functional activity of WDR24 through their influence on a variety of cellular signaling pathways. Forskolin and 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) enhance WDR24's activity by elevating intracellular cAMP, subsequently activating protein kinase A (PKA). PKA can then phosphorylate proteins that either interact with or regulate WDR24, thereby enhancing its activity. Similarly, ionomycin and A-23187 increase intracellular calcium concentrations, potentially activating calcium-dependent proteins that modulate WDR24's function. Phorbol 12-myristate 13-acetate (PMA) engages protein kinase C (PKC), which may phosphorylate substrates that enhance the interaction capabilities of WDR24, while FTY720 influences sphingosine 1-phosphate receptor signaling, leading to effects that may include the enhancement of WDR24 function.
Further indirect activation of WDR24 is achieved through the inhibition of key signaling molecules by compounds such as LY294002, a PI3K inhibitor, and PD98059, a MEK inhibitor, which can lead to upregulated activity of WDR24 by disinhibiting regulatory pathways. U0126 and SB203580, both inhibitors in the MAPK signaling pathway, may shift the signaling equilibrium to favor pathways involving WDR24, thereby enhancing its activity. Thapsigargin contributes to this enhancement by disrupting calcium homeostasis, which may activate calcium-dependent proteins that interact with WDR24. Lastly, epigallocatechin gallate (EGCG), through its antioxidant properties, modulates several signaling pathways, which might lead to an indirect increase in WDR24's functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin acts by activating adenylyl cyclase, increasing intracellular cAMP levels. This rise in cAMP can lead to activation of PKA, which may phosphorylate WDR24 or associated regulatory proteins, enhancing WDR24 activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin and other calcium-binding proteins that influence the function of WDR24 through calcium-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC) which can phosphorylate a myriad of proteins, including those that interact with WDR24, potentially enhancing WDR24's protein-protein interaction capabilities. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. PKA can subsequently phosphorylate proteins involved in the biological processes that WDR24 is implicated in, thereby enhancing WDR24 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A-23187 is an ionophore that increases intracellular calcium levels, activating calcium-dependent protein kinases which can indirectly enhance WDR24 function. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 is a sphingosine 1-phosphate receptor modulator. By influencing this receptor's signaling, it can lead to downstream effects that may include the enhanced activity of WDR24 through complex sphingolipid signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium which could activate pathways that indirectly enhance WDR24 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can increase the activity of downstream proteins by inhibiting a negative regulatory pathway, potentially leading to the enhanced activity of WDR24. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor and could alter signaling dynamics to favor pathways in which WDR24 plays a role, thereby enhancing its activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor, altering the MAPK/ERK pathway. Disruption of this pathway could indirectly upregulate or enhance the activity of WDR24 in related signaling pathways. | ||||||