Date published: 2025-12-17

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WDFY3 Inhibitors

WDFY3 inhibitors belong to a specialized category of chemical compounds that have gained prominence in the field of molecular biology and cellular processes. WDFY3, also known as WD Repeat and FYVE Domain Containing 3, is a multi-domain protein that plays a versatile role in various intracellular activities. This protein is characterized by its unique combination of WD40 repeats and a FYVE domain, which are known for their involvement in protein-protein interactions and membrane-binding events, respectively. WDFY3 is primarily recognized for its participation in endosomal trafficking, autophagy, and the regulation of vesicle transport within cells. WDFY3 inhibitors are chemical compounds designed to interact with WDFY3, potentially disrupting its various functions and modulating cellular processes that rely on this versatile protein.

The mechanism of action of WDFY3 inhibitors typically involves their binding to specific domains or regions of the WDFY3 protein, which can lead to alterations in its interactions with other cellular components or its membrane-binding abilities. By interfering with these critical functions, WDFY3 inhibitors may influence processes such as endosomal trafficking and autophagy, shedding light on the molecular mechanisms that govern these cellular activities. The study of WDFY3 inhibitors is instrumental in advancing our understanding of intracellular trafficking, vesicle transport, and membrane dynamics, offering insights into the intricate regulatory networks that ensure proper cellular function. Moreover, it contributes to the broader field of cell biology and molecular biology research, providing valuable tools for investigating the roles of WDFY3 in various cellular contexts.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Doxorubicin

23214-92-8sc-280681
sc-280681A
1 mg
5 mg
$173.00
$418.00
43
(3)

Doxorubicin intercalates DNA and inhibits topoisomerase II, leading to DNA damage and potentially reduced transcription of various genes including WDFY3.

Camptothecin

7689-03-4sc-200871
sc-200871A
sc-200871B
50 mg
250 mg
100 mg
$57.00
$182.00
$92.00
21
(2)

Camptothecin inhibits topoisomerase I, preventing DNA relegation and possibly decreasing transcription of some genes.

Mitomycin C

50-07-7sc-3514A
sc-3514
sc-3514B
2 mg
5 mg
10 mg
$65.00
$99.00
$140.00
85
(5)

Mitomycin C forms cross-links within DNA, potentially inhibiting DNA replication and transcription processes, which may reduce gene expression.

Mithramycin A

18378-89-7sc-200909
1 mg
$54.00
6
(1)

Mithramycin A binds to DNA and inhibits RNA polymerase, which may suppress the transcription of genes like WDFY3.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$36.00
$149.00
11
(1)

5-Fluorouracil is metabolized to nucleotide analogs that interfere with DNA and RNA synthesis, which might affect protein expression.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

EGCG has been shown to affect gene expression through epigenetic modifications which can lead to downregulation of certain genes.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Dactinomycin binds to DNA and interferes with RNA synthesis, which can suppress transcription and thereby decrease protein expression.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Bortezomib inhibits the proteasome, leading to increased protein turnover and potentially altered regulation of protein expression.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$32.00
$170.00
$385.00
63
(1)

Etoposide inhibits topoisomerase II, which could lead to DNA damage and potentially altered gene expression.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Chloroquine raises endosomal pH and can affect cellular processes including degradation and potentially gene expression.