VSTM1 Inhibitors
VSTM1 Inhibitors addresses various aspects of cellular signaling pathways that VSTM1 might be involved in. Wortmannin and LY294002 function as PI3K inhibitors and would directly target pathways involving PI3K and its downstream components, such as Akt. On the other hand, PD98059 is specific to the MEK-ERK pathway and would be effective if VSTM1 functions within this route. These are vital signaling pathways often implicated in cellular functions such as proliferation, differentiation, and survival.
Similarly, compounds like Y-27632 and PP2 have broader roles in inhibiting specific families of kinases like ROCK and Src, respectively. These kinases are pivotal in processes like cell motility, adhesion, and migration. In this context, if VSTM1 plays a role in any of these cellular functions or is part of the signaling cascades, its activity can be indirectly reduced by these inhibitors. For example, Rapamycin would be impactful if VSTM1's role is linked to mTOR-regulated processes like cellular growth or autophagy. Thus, understanding the context of each inhibitor allows for targeted manipulation of VSTM1's cellular functions.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin blocks PI3K-dependent phosphorylation of Akt. If VSTM1 is linked to the PI3K-Akt pathway, Wortmannin can interrupt its downstream signaling, thereby inhibiting VSTM1 functionality. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits MEK1 and MEK2, thereby blocking ERK activation. If VSTM1 operates within or downstream of the MAPK/ERK pathway, its activity will be hindered. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
This compound disrupts ATP production by inhibiting hexokinase. If VSTM1 functions are energy-sensitive, then its functional integrity can be compromised. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAPK, affecting stress response mechanisms. If VSTM1 plays a role in stress responses regulated by p38 MAPK, then its activity would be reduced. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, preventing the conversion of PIP2 to PIP3. If VSTM1 is involved in the PI3K-Akt pathway, its functional activity can be restricted. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits ROCK kinases. If VSTM1 is implicated in cellular movement or cytoskeleton organization, then its activity can be reduced. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 inhibits Src family kinases. If VSTM1 interacts with Src or operates in Src-dependent pathways, its function will be diminished. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits the mTOR complex, affecting cell growth and survival. If VSTM1 is implicated in these processes, its functional role can be constrained. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Broad-spectrum kinase inhibitor. If VSTM1's function is dependent on any protein kinases, its activity would be obstructed. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor that prevents the degradation of ubiquitinated proteins. If VSTM1 is subject to ubiquitination, its activity would be altered. | ||||||