VSTM1 Activators
VSTM1 activators encompass a diverse set of chemicals that specifically target various cellular pathways and processes, leading to the modulation of VSTM1 protein. Oxidative stress, a critical regulator of cellular homeostasis, can be influenced by activators like Thymoquinone, Trolox, and Celastrol. These compounds act predominantly through the NRF2 pathway, enhancing antioxidant defenses in cells. VSTM1, if responsive to shifts in oxidative status, becomes a target. Additionally, the importance of cellular energy balance is underlined by the inclusion of A769662 and AICAR, which are AMPK activators. By modulating cellular metabolic processes governed by AMPK, these compounds can have an indirect impact on VSTM1, provided its function or expression intersects with AMPK-regulated pathways.
Another essential facet of cellular regulation involves signaling cascades, exemplified by PD153035 and Go6983. These compounds act as of EGFR and PKC, respectively. Given the vastness of signaling networks these kinases are involved in, VSTM1's modulation can be influenced if it operates within or in response to these pathways. Similarly, the unfolded protein response, a vital mechanism in protein homeostasis, is targeted by GSK2606414, a PERK. The influence of this compound on VSTM1 is contingent upon the protein's association with the UPR. On a different note, EX527's action on the SIRT1 pathway, a central player in cellular longevity and metabolism, can indirectly steer VSTM1's activity. Lastly, glutamate signaling, a prominent neurotransmitter pathway, can be tapped by VU6005649, an mGlu7 agonist, to influence VSTM1. This intricate and specific modulation of VSTM1, through various activators, underscores the complexity and interconnectedness of cellular machinery.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
NRF2 activator that augments the antioxidant defense mechanism. VSTM1 can be modulated as a response to oxidative stress changes, making Thymoquinone a potential indirect activator through its NRF2-mediated pathway influence. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $38.00 $67.00 $235.00 $678.00 $1712.00 | 39 | |
Antioxidant that modulates the redox balance. By altering cellular oxidative status, Trolox can indirectly affect VSTM1 if the protein responds to changes in redox homeostasis. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
PKC inhibitor that impacts various downstream targets. Given PKC's involvement in numerous cellular processes, VSTM1's expression or activity can be influenced if it operates within a PKC-dependent pathway. | ||||||
PD 153035 | 153436-54-5 | sc-205909 | 5 mg | $146.00 | 5 | |
EGFR inhibitor, acting on the EGFR signaling cascade. By inhibiting EGFR, PD153035 can modulate downstream targets, influencing VSTM1 if it is a part of or responds to changes in the EGFR signaling route. | ||||||
GSK 2606414 | 1337531-36-8 | sc-490182 sc-490182A | 5 mg 25 mg | $163.00 $572.00 | ||
PERK inhibitor that plays a role in the unfolded protein response (UPR). If VSTM1 is associated with the UPR, GSK2606414 can modulate its activity by affecting the overall UPR mechanism. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
AMPK activator that impacts energy homeostasis and cellular metabolism. If VSTM1 plays a role in cellular metabolic processes influenced by AMPK, A769662 can indirectly modulate VSTM1 activity. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
NRF2 activator, influencing oxidative stress defense mechanisms. By affecting NRF2-mediated pathways, Celastrol can indirectly impact VSTM1 if its activity is linked to NRF2-regulated oxidative stress responses. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $87.00 | 32 | |
SIRT1 inhibitor, targeting cellular longevity and metabolic pathways. By modulating SIRT1 activity, EX527 can influence downstream targets and processes, potentially affecting VSTM1 if it operates within SIRT1-dependent mechanisms. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMPK activator that affects cellular metabolism. If VSTM1's function or expression is influenced by AMPK-regulated metabolic pathways, AICAR can play a role in modulating its activity. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
NRF2 activator enhancing antioxidant defenses. If VSTM1's modulation is linked to NRF2-mediated oxidative stress responses, Parthenolide can play a role in its indirect activation. | ||||||