VRTN Inhibitors
VRTN inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the VRTN (Vertebrae Development Associated) protein, which plays a crucial role in vertebral patterning and development. VRTN is a transcription factor that regulates the expression of various genes involved in embryonic development, particularly those that influence the formation and segmentation of the vertebral column. The protein is known to interact with DNA, promoting the transcription of genes responsible for establishing the correct number and pattern of vertebrae. By inhibiting VRTN, these compounds can disrupt its ability to regulate gene expression, which may affect cellular differentiation and tissue development, particularly in processes related to skeletal formation.
The mechanism of action for VRTN inhibitors typically involves binding to the DNA-binding domains or other regulatory regions of the VRTN protein, preventing it from interacting with target genes and thus blocking its transcriptional activity. This inhibition alters the expression of genes critical for developmental processes, potentially leading to changes in the formation of structures regulated by VRTN. Researchers use VRTN inhibitors to study the protein's specific role in vertebrate development, gaining insights into how transcription factors like VRTN influence the precise patterning of anatomical features. By blocking VRTN function, these inhibitors provide valuable tools for exploring the complex genetic and molecular mechanisms that control vertebral segmentation and other developmental processes regulated by VRTN. Understanding these pathways helps clarify the role of transcriptional regulation in embryonic development and the maintenance of proper vertebral structure.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Inhibits the hedgehog signaling pathway which is crucial for embryonic development. VRTN inhibition may result from the disrupted hedgehog signaling affecting vertebral development. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that affects cell growth and proliferation pathways. Since VRTN is associated with vertebrae development, mTOR inhibition can impact VRTN function by limiting necessary cellular processes. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
A BMP inhibitor that blocks bone morphogenetic protein signaling, a pathway important for skeletal development. This may lead to indirect inhibition of VRTN by preventing proper vertebral formation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibits the TGF-beta signaling pathway, which is involved in the proliferation and differentiation of cells in vertebral development, potentially reducing VRTN activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can downregulate pathways essential for cell survival and growth, indirectly affecting VRTN activity by altering the cellular environment required for vertebrae development. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Inhibits Wnt production, which is necessary for the regulation of bone formation. Reduced Wnt signaling can lead to a decrease in VRTN activity. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
A selective inhibitor of ALK2 and ALK3 which are receptors for BMPs, potentially affecting the role of VRTN in vertebrae development by disrupting BMP signaling. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
An FGFR inhibitor that can impede fibroblast growth factor signaling, affecting cell division and differentiation processes that are essential for vertebral development, thus indirectly affecting VRTN. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Influences cell differentiation and is critical in vertebrate morphogenesis. Excess or deficit of retinoic acid signaling can disrupt the development process, potentially leading to decreased VRTN function. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
A CDK4/6 inhibitor that disrupts the cell cycle, potentially affecting cell proliferation and differentiation in vertebral development, thus indirectly inhibiting VRTN activity. | ||||||