VRK1 Activators
VRK1 activators are a diverse class of chemical compounds that directly or indirectly enhance the functional activity of VRK1. These activators include inhibitors of negative regulators of VRK1, such as PKC, CDKs, p38 MAPK, JNK, MEK1/2, and mTOR. By inhibiting these negative regulators, the activators indirectly enhance VRK1 activity by preventing their phosphorylation-mediated negative regulation of VRK1.
Additionally, some VRK1 activators directly interact with VRK1 itself, promoting its autophosphorylation and enhancing its kinase activity. Examples of such activators include curcumin, resveratrol, and genistein. These compounds activate specific pathways, such as the AMPK pathway, which indirectly enhance VRK1 activity. Overall, VRK1 activators encompass a wide range of chemical compounds that enhance the functional activity of VRK1 through various mechanisms. These activators either inhibit negative regulators of VRK1 or directly interact with VRK1 itself, leading to increased kinase activity and subsequent cellular responses. Understanding the functional mechanisms of VRK1 activators provides insights into the intricate regulatorynetworks that govern VRK1 activity and its involvement in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a selective inhibitor of protein kinase C (PKC) that has been shown to enhance the kinase activity of VRK1. By inhibiting PKC, it indirectly enhances VRK1 activity by preventing its negative regulation by PKC-mediated phosphorylation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of various protein kinases, including PKC. Similar to Bisindolylmaleimide I, it indirectly enhances VRK1 activity by inhibiting PKC-mediated negative regulation of VRK1. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol is a potent inhibitor of cyclin-dependent kinases (CDKs). It has been shown to enhance the kinase activity of VRK1 by inhibiting CDK-mediated phosphorylation of VRK1, which negatively regulates its activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is another CDK inhibitor that enhances the kinase activity of VRK1 by inhibiting CDK-mediated phosphorylation of VRK1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. It has been shown to enhance the kinase activity of VRK1 by inhibiting p38 MAPK-mediated phosphorylation of VRK1, which negatively regulates its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of JNK. Similar to SB203580, it enhances the kinase activity of VRK1 by inhibiting JNK-mediated phosphorylation of VRK1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an immunosuppressant that inhibits the mammalian target of rapamycin (mTOR) pathway. It has been shown to enhance the kinase activity of VRK1 by inhibiting mTOR-mediated negative regulation of VRK1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural compound found in turmeric with various biological activities. It has been shown to enhance the kinase activity of VRK1 by directly interacting with VRK1 and promoting its autophosphorylation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural compound found in grapes and red wine. It has been shown to enhance the kinase activity of VRK1 by activating the AMP-activated protein kinase (AMPK) pathway, which indirectly promotes VRK1 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a natural compound found in soybeans and other legumes. It has been shown to enhance the kinase activity of VRK1 by inhibiting tyrosine kinases, such as epidermal growth factor receptor (EGFR), which negatively regulate VRK1. | ||||||