VPS37B Activators
VPS37B activators encompass a range of chemical compounds that indirectly influence the activity of the VPS37B protein by modulating cellular processes and pathways related to endosomal sorting and trafficking. The chemicals listed above, such as Monensin, Bafilomycin A1, and Dynasore, primarily function by altering the dynamics of endosomal acidification, endocytic processes, or the assembly of endosomal sorting complexes. These alterations can, in turn, impact the function of VPS37B in the ESCRT-I complex, which is crucial for the sorting of ubiquitinated membrane proteins into multivesicular bodies.
The disruption or modulation of these pathways by the chemicals can lead to changes in the intracellular trafficking and sorting mechanisms. For example, inhibitors of vacuolar-type H+-ATPase, like Bafilomycin A1, can affect the acidification of endosomes, a key process in the sorting of proteins for degradation or recycling. Similarly, compounds that inhibit dynamin, such as Dynasore, affect clathrin-mediated endocytosis, a pathway closely related to the function of the ESCRT machinery, including VPS37B.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin, a carboxylic ionophore, disrupts endosomal pH and trafficking, potentially affecting VPS37B-related pathways. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
As a specific inhibitor of the vacuolar-type H+-ATPase, Bafilomycin A1 alters endosomal acidification, indirectly influencing VPS37B function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
This small molecule inhibits dynamin, impacting clathrin-mediated endocytosis and potentially affecting VPS37B-mediated sorting. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 inhibits clathrin-mediated endocytosis, which could indirectly modulate VPS37B activity by altering endosomal trafficking. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Known to disrupt clathrin-mediated endocytosis, Chlorpromazine can indirectly influence VPS37B function. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $104.00 | 20 | |
EIPA blocks macropinocytosis and endocytosis, potentially affecting processes related to VPS37B. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
By inhibiting tyrosine kinases, Genistein can modulate various signaling pathways, potentially influencing VPS37B activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
As a PI3 kinase inhibitor, Wortmannin affects endocytic trafficking, potentially impacting VPS37B-related functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This PI3K inhibitor can alter endocytic processes, indirectly affecting the role of VPS37B in endosomal sorting. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Amiloride, primarily a diuretic, can influence endocytic pathways, potentially affecting VPS37B activity. | ||||||