VPS33A Activators
The class of molecules known as VPS33A activators encompasses a variety of chemicals that affect vesicle trafficking, either by acting on the formation, transport, or fusion of vesicles or by altering the phosphorylation status of proteins involved in these processes. These molecules indirectly influence the activity of VPS33A, which is an integral part of the HOPS complex that facilitates vesicle fusion.
Phosphatidylinositol 4,5-bisphosphate, for instance, is involved in the formation of vesicles at the plasma membrane, a process that is linked to the function of VPS33A in vesicle fusion. Certain ionophores and compounds like brefeldin A can disrupt vesicle trafficking, potentially leading to compensatory increases in VPS33A activity. Protein kinase C activators and protein phosphatase inhibitors, such as PMA, calyculin A, and okadaic acid, might change the phosphorylation status of proteins involved in vesicle trafficking, offering another route to modulate VPS33A activity. Finally, inhibitors of GTPases and compounds that affect the cytoskeleton, such as dynasore, nocodazole, latrunculin A, cytochalasin D, and taxol, can disrupt vesicle transport, potentially leading to changes in VPS33A activity as the cell attempts to maintain proper vesicle trafficking.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a sodium ionophore that disrupts vesicle trafficking, which could lead to compensatory increases in the activity of vesicle fusion machinery, including VPS33A. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits the formation of transport vesicles from the Golgi, an event that could indirectly modulate the activity of VPS33A by altering the overall vesicle trafficking process. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a variety of proteins involved in vesicle trafficking and could indirectly modulate VPS33A activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a protein phosphatase inhibitor and could potentially modulate VPS33A activity by changing the phosphorylation status of proteins involved in vesicle trafficking. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that affects vesicle trafficking and could indirectly influence VPS33A. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a protein phosphatase inhibitor that could potentially modulate VPS33A activity by changing the phosphorylation status of proteins involved in vesicle trafficking. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that disrupts endocytosis, a process that could indirectly influence the activity of VPS33A. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules and therefore vesicle transport, potentially leading to compensatory changes in VPS33A activity. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts actin filaments and therefore vesicle transport, potentially leading to compensatory changes in VPS33A activity. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filaments and therefore vesicle transport, potentially leading to compensatory changes in VPS33A activity. | ||||||