VPS26 Activators
VPS26 is key in the retromer complex, which is critical for the retrieval of various transmembrane proteins from endosomes to the trans-Golgi network. Chemicals like Bafilomycin A1 and Concanamycin A act by inhibiting vacuolar-type H+-ATPase, impeding the acidification of endosomes and thus promoting the recycling pathway where VPS26 functions. Similarly, Chloroquine, Monensin, and Nigericin disrupt endosomal acidification, indirectly enhancing VPS26's activity. These chemicals, by disrupting endosome to lysosome trafficking, reroute the trafficking towards the recycling pathway, thereby increasing the functional demand for VPS26.
In contrast, Wortmannin enhances VPS26 activity by inhibiting phosphoinositide 3-kinases (PI3Ks). PI3Ks play a key role in endosomal trafficking, and their inhibition can lead to the accumulation of endosomes. This increases the need for the retromercomplex, thereby enhancing the activity of VPS26. Similarly, Dynasore, an inhibitor of dynamin that plays a role in endocytosis, also enhances VPS26 activity by increasing the demand for the retromer complex. Certain chemicals disrupt microtubule dynamics, which are crucial for endosomal trafficking. Vinblastine and Nocodazole, by disrupting microtubule dynamics, increase the functional demand for VPS26 as they lead to an increase in the need for the retromer complex. Furthermore, Genistein and Tyrphostin AG1478, potent inhibitors of tyrosine kinases, can also promote the recycling pathway where VPS26 functions. By inhibiting these kinases, they reroute the trafficking towards the recycling pathway, thereby enhancing the activity of VPS26. In summary, all these chemicals, in one way or another, increase the functional demand for VPS26, leading to its enhanced activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of vacuolar-type H+-ATPase. By inhibiting the H+-ATPase, it prevents the acidification of endosomes, promoting the recycling pathway in which VPS26 is involved. This leads to enhanced activity of VPS26. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is a weak base that accumulates in acidic compartments such as endosomes and lysosomes, raising their pH. This disrupts endosome to lysosome trafficking, enhancing the recycling pathway in which VPS26 is involved, thereby leading to enhanced activity of VPS26. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of phosphoinositide 3-kinases (PI3Ks). Inhibition of PI3Ks by wortmannin can lead to the accumulation of endosomes, potentially increasing the demand for the retromer complex, and thereby enhancing the activity of VPS26. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that disrupts endosomal pH by altering ion gradients. This leads to the disruption of endosome to lysosome trafficking, enhancing the recycling pathway in which VPS26 is involved, thereby enhancing the activity of VPS26. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $46.00 $112.00 $240.00 $7079.00 $27417.00 | 9 | |
Nigericin is an ionophore that disrupts the pH of endosomes by altering ion gradients. This disrupts endosome to lysosome trafficking, enhancing the recycling pathway in which VPS26 is involved, thereby enhancing the activity of VPS26. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a cell-permeable inhibitor of dynamin, which is involved in endocytosis. By inhibiting endocytosis, it increases the need for the retromer complex and thereby enhances the activity of VPS26. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A is a specific inhibitor of vacuolar-type H+-ATPase, preventing the acidification of endosomes. This promotes the recycling pathway in which VPS26 is involved, leading to enhanced activity of VPS26. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule dynamics, affecting endosomal trafficking. This increases the demand for the retromer complex and thereby enhances the activity of VPS26. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, disrupting endosomal trafficking. This increases the need for the retromer complex and thereby enhances the activity of VPS26. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a potent inhibitor of tyrosine kinases, which are involved in endocytic sorting. By inhibiting these kinases, it can promote the recycling pathway in which VPS26 is involved, thereby enhancing the activity of VPS26. | ||||||