VPS26 Antibody (E-3): sc-390304

VPS26 Antibody (E-3) is a mouse monoclonal IgM antibody that detects VPS26 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-VPS26 antibody (E-3) is available as the non-conjugated form. VPS26, also known as vacuolar protein sorting 26 or VPS26A, is a crucial component of the retromer complex, which is essential for the retrograde transport of proteins from endosomes back to the trans-Golgi network. This transport mechanism maintains cellular homeostasis and ensures proteins are delivered to their correct destinations, preventing accumulation of mislocalized proteins that could disrupt cellular function. VPS26 consists of 327 amino acids and is predominantly expressed in tissues such as the heart, liver, kidney, placenta, and skeletal muscle, where VPS26 plays a significant role in protein trafficking. VPS26 interacts with other proteins in the retromer complex, including VPS26B and VPS35, highlighting VPS26′s importance in intracellular transport. Multiple isoforms of VPS26 arise from alternative splicing, contributing to functional diversity in various cellular contexts.

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VPS26 Antibody (E-3) References:

1. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.  |  Haft, CR., et al. 2000. Mol Biol Cell. 11: 4105-16. PMID: 11102511
2. Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval.  |  Reddy, JV. and Seaman, MN. 2001. Mol Biol Cell. 12: 3242-56. PMID: 11598206
3. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.  |  Vergés, M., et al. 2004. Nat Cell Biol. 6: 763-9. PMID: 15247922
4. A novel mammalian retromer component, Vps26B.  |  Kerr, MC., et al. 2005. Traffic. 6: 991-1001. PMID: 16190980
5. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain.  |  Shi, H., et al. 2006. Nat Struct Mol Biol. 13: 540-8. PMID: 16732284
6. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.  |  Rojas, R., et al. 2007. Mol Cell Biol. 27: 1112-24. PMID: 17101778
7. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.  |  Mao, M., et al. 1998. Proc Natl Acad Sci U S A. 95: 8175-80. PMID: 9653160

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VPS26 Antibody (E-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-VPS26 Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VPS26 Antibody (E-3) Specifications

Alternate Product Name: VPS26

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 81-117

Epitope Target: VPS26

Epitope Species: human

Product Reactivity/Detection: VPS26

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for VPS26 Antibody (E-3): P: Blocking Peptide