VPS13D Activators
VPS13D activators comprise a set of chemical compounds that indirectly bolster the functionality of VPS13D through modulation of various cellular signaling pathways. Forskolin, by increasing the levels of cAMP within the cell, can activate PKA, which in turn may phosphorylate protein targets that enhance the autophagic and mitochondrial maintenance roles of VPS13D. Similarly, sphingosine-1-phosphate influences receptor-mediated signaling pathways that support VPS13D's involvement in membrane dynamics and trafficking. The polyphenol compound epigallocatechin gallate (EGCG), recognized for its antioxidant properties, can modulate kinase activities, potentially improving VPS13D's protective role against cellular stress by enhancing its function. The PI3K inhibitor LY294002, alongside the well-known mTOR pathway inhibitor rapamycin, can upregulate autophagic pathways, consequently leading to increased VPS13D activity, a protein that is intricately associated with autophagy.
Further influencing VPS13D activity are resveratrol and metformin, which activate SIRT1 and AMPK respectively, both of which are key regulators of autophagy, suggesting a potential indirect enhancement of VPS13D's role in this process. Nicotinamide mononucleotide (NMN), as a precursor to NAD+, can boost sirtuin activity and autophagy, thereby possibly enhancing VPS13D function. Curcumin, with its ability to modulate autophagic pathways, and lithium, which activates the Wnt/β-catenin signaling pathway, could also support VPS13D's functional role in cellular trafficking processes. Additionally, 17-AAG, an Hsp90 inhibitor, may induce a heat shock response that stabilizes and promotes VPS13D's function under stress conditions. Lastly, retinoic acid, by influencing geneexpression and cellular differentiation processes, could indirectly augment VPS13D's involvement in endolysosomal trafficking. These activators, through their distinct mechanisms, collectively enhance the functional activity of VPS13D without necessitating direct activation or increased expression of the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can activate PKA. PKA phosphorylation may enhance the functional activity of VPS13D by promoting its role in mitochondrial maintenance and autophagy. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P binds to its receptors leading to activation of intracellular signaling pathways. This can enhance the membrane dynamics and trafficking functions associated with VPS13D. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG acts as an antioxidant and has been shown to modulate kinase activity, potentially enhancing the protective role of VPS13D in cellular stress responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that may upregulate autophagic processes, potentially leading to increased VPS13D activity as it is involved in autophagy. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, which induces autophagy. Given VPS13D's role in this process, rapamycin could enhance its functional activity by increasing autophagic flux. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, leading to deacetylation of proteins involved in autophagy, potentially enhancing the activity of VPS13D in this pathway. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, which can enhance autophagy and may indirectly increase the activity of VPS13D involved in this process. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN is a precursor to NAD+, which is crucial for sirtuin function. Elevated sirtuin activity can enhance autophagy and possibly VPS13D function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate autophagic pathways, potentially enhancing VPS13D function in autophagy through indirect pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium activates the Wnt/β-catenin pathway, which might indirectly enhance VPS13D's function related to endosomal trafficking. | ||||||