Vmn1r90 Inhibitors
Chemical inhibitors of vomeronasal 1 receptor 90 (V1R90) employ various mechanisms to disrupt its function. Capsaicin, for example, binds directly to TRPV1 receptors, which have a complex interplay with V1R90. Through this binding, capsaicin alters the conformation of these TRPV1 receptors, which in turn hinders the functional capability of V1R90 by preventing its typical ligand binding and activation. Similarly, chloroquine impacts V1R90 indirectly by accumulating in acidic vesicles and increasing their pH, which can impede the trafficking of the receptor to the membrane, a process essential for its activation. Ruthenium Red and verapamil both act on calcium channels, with the former blocking them and the latter inhibiting calcium influx. Given the calcium-dependency of V1R90 signaling, these actions result in the inhibition of the receptor's signaling cascade.
Further disrupting V1R90 signaling, suramin inhibits purinergic receptors, which can lower calcium levels and thus impede V1R90 function. BAPTA, by sequestering intracellular calcium, and thapsigargin, by depleting calcium stores via SERCA inhibition, also lead to a reduction in the calcium-dependent signaling pathways upon which V1R90 relies. Genistein's approach involves the inhibition of tyrosine kinases, which are vital for the phosphorylation processes that V1R90 needs for signal transduction. ML-7 and Y-27632 disrupt the cytoskeletal dynamics by inhibiting myosin light chain kinase and ROCK, respectively, which are necessary for the proper signaling and expression of V1R90. Finally, U73122 and NF449 specifically target elements of the G-protein signaling pathway; U73122 inhibits phospholipase C, while NF449 is selective for the Gs-alpha subunit, both leading to a downregulation of the receptor's activity by hampering necessary signaling events.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin binds to and activates TRPV1 receptors which are known to form complexes with vomeronasal 1 receptor 90 (V1R90), leading to its functional inhibition by altering receptor conformation and preventing its normal ligand binding and activation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine accumulates in acidic vesicles, raising their pH, which can inhibit the function of V1R90 by disrupting the receptor trafficking to the membrane, necessary for its activation. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red is known to block calcium channels. Since V1R90 signaling is dependent on intracellular calcium levels, blocking these channels can inhibit the signaling cascade that V1R90 is part of. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin inhibits purinergic signaling by blocking P2 receptors, which could inhibit V1R90 through downstream effects on calcium signaling pathways that are essential for V1R90 function. | ||||||
BAPTA, Free Acid | 85233-19-8 | sc-201508 sc-201508A | 100 mg 500 mg | $68.00 $267.00 | 10 | |
BAPTA acts as a calcium chelator, and by sequestering intracellular calcium, it can inhibit the calcium-dependent signaling pathways that V1R90 relies on for its activation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). By inhibiting MLCK, the cytoskeletal changes required for proper V1R90 signaling are prevented, leading to an inhibition of V1R90 function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to a depletion of calcium stores. This depletion can inhibit V1R90 by disrupting necessary calcium signaling. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, and by inhibiting these kinases it can prevent phosphorylation events required for V1R90 signal transduction, leading to inhibition of the receptor's function. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that can inhibit the influx of calcium ions. Reduced calcium influx can inhibit the activation and function of V1R90, which is dependent on calcium signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits ROCK, a Rho-associated protein kinase. Inhibition of ROCK affects cytoskeletal dynamics and cell adhesion, which are important for the functional expression and signaling of V1R90. | ||||||