VHL Activators
Common VHL Activators include, but are not limited to Dimethyloxaloylglycine (DMOG) CAS 89464-63-1, Cholecalciferol CAS 67-97-0, Trichostatin A CAS 58880-19-6, Cadmium chloride, anhydrous CAS 10108-64-2 and Rosiglitazone CAS 122320-73-4.
VHL (von Hippel-Lindau) Activators belong to a specialized chemical class that has garnered scientific interest for their ability to modulate the activity of the von Hippel-Lindau protein, known as VHL. VHL is a key player in cellular homeostasis as it plays a central role in the regulation of hypoxia-inducible factors (HIFs) through a process involving ubiquitin-mediated degradation. HIFs are transcription factors that orchestrate cellular responses to low oxygen levels, controlling the expression of genes involved in diverse processes such as angiogenesis, metabolism, and erythropoiesis. VHL Activators operate by influencing the interactions and pathways involving VHL, thereby influencing its capability to target HIFs for degradation, thereby impacting cellular responses to changes in oxygen availability.
Developing VHL Activators involves a deep understanding of the structural attributes of VHL, its interactions with HIFs, and the intricate mechanisms of the ubiquitin-proteasome system. Researchers in this field focus on engineering molecules that enhance the activation of VHL, aiming to refine its role in modulating cellular responses to hypoxia. These activators often utilize innovative design strategies that bolster VHL's functional capacity to tag HIFs for degradation, ultimately influencing the balance of gene expression in hypoxic conditions. By unraveling the complexities of VHL-mediated processes, researchers gain insights into its fundamental significance within cellular adaptation to varying oxygen levels. Continuous advancements in molecular pharmacology and chemical synthesis drive the ongoing evolution of VHL Activators, offering applications across various scientific disciplines where manipulation of VHL-mediated pathways is a subject of interest.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $82.00 $295.00 $367.00 $764.00 | 25 | |
DMOG is a prolyl hydroxylase inhibitor that stabilizes HIF and can indirectly influence VHL expression through HIF-mediated feedback mechanisms. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D and its active form calcitriol can influence gene expression, including potential effects on VHL expression, which may impact various physiological processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor that affects chromatin structure and gene expression, potentially influencing VHL expression through epigenetic mechanisms. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium chloride is a chemical stressor that can impact gene expression patterns, including potential effects on VHL expression, due to its toxicological properties. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a PPARγ agonist that can modulate gene expression, including VHL, through interactions with nuclear receptors involved in metabolism and inflammation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an autophagy inducer that can modulate autophagic processes, potentially impacting VHL expression as part of cellular stress responses. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that affects protein degradation processes and might influence VHL expression by altering protein turnover rates. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin is an anti-inflammatory agent that can modulate gene expression, including genes related to inflammation like VHL, through its anti-inflammatory properties. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin is an inducer of heat shock proteins (HSPs), which might indirectly influence VHL expression through heat shock responses and stress-related pathways. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-deoxycytidine is a DNA methyltransferase inhibitor that can impact epigenetic modifications and potentially influence VHL expression through epigenetic regulation. | ||||||