VENTX2 Activators
VENTX2 activators operate through a variety of biochemical mechanisms to enhance the functional activity of this transcription factor. One major pathway for the activation of VENTX2 involves the elevation of intracellular cyclic AMP (cAMP) levels. This activation can occur through the stimulation of adenylate cyclase by agonists that act on G-protein coupled receptors, leading to increased cAMP synthesis. Once cAMP is accumulated, it activates protein kinase A (PKA), which phosphorylates specific transcription factors that enhance the transcriptional activity of VENTX2. Additionally, the activation of protein kinase C (PKC) through direct binding agents also plays a significant role in modulating transcription factors that govern VENTX2 expression, thus increasing its activity. The prevention of cAMP degradation by phosphodiesterase inhibitors further sustains PKA signaling, leading to a more prolonged and potent activation of VENTX2.
Other activators work by initiating secondary pathways that ultimately converge on the regulation of VENTX2. For instance, stress-activated protein kinases can be stimulated by agents that interfere with protein synthesis, setting off a cascade that might augment the cellular stress responses and lead to increased VENTX2 activity. Additionally, the modulation of intracellular calcium levels can activate PKC, which subsequently influences the transcriptional regulation of VENTX2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. VENTX2 activity is enhanced via cAMP response element-binding protein (CREB) phosphorylation, which can promote its transcriptional activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A synthetic catecholamine that activates beta-adrenergic receptors, leading to cAMP accumulation. Elevated cAMP levels promote VENTX2 activation through protein kinase A (PKA)-mediated signaling cascades. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diester of phorbol that activates protein kinase C (PKC), which can enhance VENTX2 activity by modulating transcription factors that control its expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cell-permeable cAMP analog that directly activates PKA, leading to the phosphorylation of transcription factors involved in VENTX2 expression. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Acts on adrenergic receptors to increase cAMP levels, indirectly promoting VENTX2 activation via PKA-mediated signaling. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Binds to H2 receptors, causing an increase in intracellular cAMP, which indirectly supports VENTX2 transcriptional activity through PKA-dependent pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Engages G-protein coupled receptors (GPCRs) and raises cAMP levels, facilitating VENTX2 activation through PKA signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, prevents cAMP degradation, supporting VENTX2 activation through sustained PKA signaling. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
A selective inhibitor of phosphodiesterase 4 (PDE4), increasing cAMP levels and indirectly promoting VENTX2 activation through PKA-dependent pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
A protein synthesis inhibitor that activates stress-activated protein kinases, potentially enhancing VENTX2 activity by altering the cellular stress response. | ||||||