VAX1 Activators
VAX1 activators encompass a spectrum of chemical compounds that indirectly promote the functional activity of VAX1 through modulationof specific biochemical pathways. Retinoic Acid and Folic Acid enhance VAX1 activity by impacting gene expression; Retinoic Acid does so through the RAR-RXR pathway, which influences neuronal development genes, while Folic Acid affects DNA methylation processes critical for cell proliferation. Sodium Butyrate, as an HDAC inhibitor, can make developmental genes more transcriptionally active, potentially amplifying VAX1's role in development. Nicotinamide, through its effect on NAD+ and sirtuins, supports cellular repair mechanisms, likely benefiting VAX1's role in neural tube closure. Forskolin and Dibutyryl cAMP, by elevating intracellular cAMP levels and activating PKA, can modify transcription factor activity, which may in turn enhance VAX1's developmental functions. Lithium Chloride and Picrotoxin, although acting through GSK-3 inhibition and GABA_A receptor antagonism respectively, may bolster neuronal activity and development, a domain where VAX1 is crucial. Concanavalin A, through its impact on glycosylation, and Epigallocatechin Gallate (EGCG), which modulates kinase activity, have the potential to fine-tune cell signaling processes that indirectly enhance VAX1's role in development.
The functional activity of VAX1 is further influenced by compounds that affect cellular signaling pathways involved in growth and development. K252a, by inhibiting PKC, impacts neural growth and development signaling pathways, potentially creating conditions that favor VAX1 activity. These VAX1 activators, through their targeted effects on cellular signaling, facilitate the enhancement of VAX1's role in development and differentiation processes. By strategically influencing pathways that VAX1 is involved in, these compounds do not simply upregulate its expression but enhance the quality and scope of its functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid interacts with retinoic acid receptors (RARs) which heterodimerize with retinoid X receptors (RXRs), and these complexes can regulate gene expression, including genes involved in neuronal development. Since VAX1 is known to play a role in craniofacial development and neuronal growth, the RAR-RXR pathway activation by Retinoic Acid may facilitate the functional activity of VAX1 in cell differentiation and tissue development. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic Acid is crucial for DNA methylation and synthesis. It contributes to the regulation of gene expression by influencing epigenetic mechanisms, which can affect the functional activity of VAX1 in cell proliferation and neural tube closure. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, functions as a precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in redox reactions. NAD+ can influence the activity of sirtuins and poly(ADP-ribose) polymerases (PARPs) that are involved in DNA repair and gene expression. Thus, nicotinamide may indirectly enhance the function of VAX1 through these cellular repair and maintenance mechanisms. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, a short-chain fatty acid, is a histone deacetylase (HDAC) inhibitor that can lead to the acetylation of histones and relaxed chromatin, making certain regions of the genome more accessible for transcription. Enhanced transcription of developmental genes could indirectly include increased functional activity of VAX1 in developmental processes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which subsequently activate PKA. PKA phosphorylation can lead to changes in the activity of transcription factors and gene expression, potentially enhancing VAX1 activity in developmental signaling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3, leading to the stabilization and accumulation of β-catenin, a component of the Wnt signaling pathway. Although not a direct activator of VAX1, the augmented Wnt signaling might support the developmental processes VAX1 is a part of. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $66.00 $280.00 $1300.00 | 11 | |
Picrotoxin is a GABA_A receptor antagonist that can increase neuronal excitability by inhibiting the inhibitory neurotransmitter system. Increased neuronal activity may indirectly enhance the functional role of VAX1 in the development of the nervous system. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $117.00 $357.00 $928.00 | 17 | |
Concanavalin A is a lectin that binds to glucose and mannose residues, potentially affecting glycosylation patterns on proteins and altering signaling pathways. Altered glycosylation can influence cell signaling and adhesion, indirectly affecting VAX1’s role in development. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate is a polyphenol that can influence several signaling pathways, including inhibition of various kinases. By modulating kinase activity, EGCG could potentially enhance VAX1 activity by affecting signaling pathways that regulate development and differentiation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cAMP analog that can permeate cell membranes and activate PKA. By mimicking cAMP's role in cell signaling, it can enhance the phosphorylation of transcription factors that regulate gene expression relevant to VAX1’s functional role in development. | ||||||