V1RG5 Inhibitors
V1RG5 inhibitors represent a distinct class of chemical compounds that specifically target and impede the activity of the V1RG5 protein, a component of the vacuolar-type H+-ATPase (V-ATPase) complex. The V-ATPase complex is a crucial molecular machine involved in maintaining acidic environments within various intracellular compartments, such as lysosomes, endosomes, and vacuoles, by pumping protons across cellular membranes. V1RG5 is a subunit of the V1 domain of this complex, playing a vital role in the ATP-driven process that powers the proton pumping. This subunit is integral to the proper assembly and functioning of the V1 domain, which is responsible for the hydrolysis of ATP, providing the necessary energy for the proton transport.
The mechanism of action for V1RG5 inhibitors involves binding to the V1RG5 protein and disrupting its normal role within the V-ATPase complex. By interacting specifically with V1RG5, these inhibitors can hinder the assembly or activity of the V1 domain, thereby affecting the ATP hydrolysis process and, consequently, the proton-pumping function of the V-ATPase. This disruption can impact the pH regulation within the cell and alter the function of cellular compartments dependent on V-ATPase activity. The study of V1RG5 inhibitors provides valuable insights into the operational mechanics of the V-ATPase complex and helps elucidate the role of V1RG5 in cellular proton transport and pH homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to intracellular calcium depletion, which may downregulate V1R74 expression. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic acid inhibits SERCA, leading to intracellular calcium depletion, which may downregulate V1R74 expression. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil inhibits L-type calcium channels, potentially reducing intracellular calcium levels and inhibiting the calcium-dependent signaling pathways involved in V1R74 expression. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine inhibits L-type calcium channels, potentially reducing intracellular calcium levels and inhibiting the calcium-dependent signaling pathways involved in V1R74 expression. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red is a calcium channel blocker that inhibits calcium influx, potentially interfering with the calcium-dependent signaling pathways involved in V1R74 expression. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 inhibits store-operated calcium entry (SOCE), potentially reducing intracellular calcium levels and inhibiting the calcium-dependent signaling pathways involved in V1R74 expression. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $153.00 $357.00 | 4 | |
Gadolinium chloride inhibits non-selective cation channels, potentially reducing intracellular calcium levels and inhibiting the calcium-dependent signaling pathways involved in V1R74 expression. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits calcium release from the sarcoplasmic reticulum, potentially reducing intracellular calcium levels and inhibiting the calcium-dependent signaling pathways involved in V1R74 expression. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
EGTA is a calcium chelator that reduces intracellular calcium levels, potentially inhibiting the calcium-dependent signaling pathways involved in V1R74 expression. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator that reduces intracellular calcium levels, potentially inhibiting the calcium-dependent signaling pathways involved in V1R74 expression. | ||||||