Date published: 2026-2-14

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V1RC10 Activators

Chemical activators of V1RC10 can engage in various cellular signaling pathways that ultimately lead to the functional activation of the protein. Forskolin, a diterpene, is known to directly stimulate adenylate cyclase, which catalyzes the conversion of ATP to cyclic AMP (cAMP). An increase in intracellular cAMP levels can activate protein kinase A (PKA), a kinase that may phosphorylate V1RC10, leading to its activation. A similar mechanism of action is employed by Isoproterenol, PGE2, Histamine, Dopamine, Adenosine, and Glucagon. These chemicals function by binding to their respective receptors, which are coupled to G proteins that activate adenylate cyclase. The ensuing rise in cAMP levels results in PKA activation. PKA then has the potential to phosphorylate and activate V1RC10. This cascade of events ensures that V1RC10 is regulated by a diverse set of ligands, reflecting its role in various physiological processes.

Additionally, some chemicals activate V1RC10 through modulation of intracellular calcium levels. Ibotenic Acid, a neurotoxic secondary metabolite, acts as an agonist for glutamate receptors and can induce an increase in intracellular calcium concentration. This elevation of calcium can activate a range of calcium-dependent kinases capable of phosphorylating V1RC10. Nicotine and Capsaicin, on the other hand, directly bind to their respective receptors, namely nicotinic acetylcholine receptors and TRPV1 receptors. Activation of these receptors results in an influx of calcium ions, which can activate kinases that phosphorylate and activate V1RC10. Similarly, Acetylcholine can activate muscarinic receptors coupled to Gq proteins, leading to the activation of phospholipase C, production of inositol trisphosphate, release of intracellular calcium stores, and subsequent activation of kinases that may target and activate V1RC10. These distinct mechanisms highlight the intricate regulatory network that can converge on the activation of V1RC10, underlining its potential responsiveness to a wide range of extracellular signals.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Isoproterenol Hydrochloride

51-30-9sc-202188
sc-202188A
100 mg
500 mg
$28.00
$38.00
5
(0)

Agonist for beta-adrenergic receptors, stimulates adenylate cyclase via Gs protein, increasing cAMP and activating PKA, which could result in V1RC10 activation.

PGE2

363-24-6sc-201225
sc-201225C
sc-201225A
sc-201225B
1 mg
5 mg
10 mg
50 mg
$57.00
$159.00
$275.00
$678.00
37
(1)

Binds to EP2/EP4 receptors, which can stimulate adenylate cyclase, boosting cAMP levels and activating PKA that may phosphorylate and activate V1RC10.

Ibotenic acid

2552-55-8sc-200449
sc-200449A
1 mg
5 mg
$120.00
$420.00
1
(1)

Glutamate receptor agonist which can lead to increased intracellular calcium levels, thereby activating kinases that may phosphorylate and activate V1RC10.

Histamine, free base

51-45-6sc-204000
sc-204000A
sc-204000B
1 g
5 g
25 g
$94.00
$283.00
$988.00
7
(1)

Activates H2 receptors that stimulate adenylate cyclase, increase cAMP, and activate PKA, possibly leading to V1RC10 activation.

Dopamine

51-61-6sc-507336
1 g
$290.00
(0)

Binds to D1-like receptors, stimulating adenylate cyclase, raising cAMP levels, and activating PKA, which could activate V1RC10.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$96.00
$160.00
$240.00
$405.00
26
(1)

Activates TRPV1 receptors leading to an influx of calcium ions which can activate downstream kinases that phosphorylate and activate V1RC10.

Adenosine

58-61-7sc-291838
sc-291838A
sc-291838B
sc-291838C
sc-291838D
sc-291838E
sc-291838F
1 g
5 g
100 g
250 g
1 kg
5 kg
10 kg
$34.00
$48.00
$300.00
$572.00
$1040.00
$2601.00
$4682.00
1
(0)

Through A2 receptors, increases adenylate cyclase activity, raises cAMP levels and activates PKA, potentially leading to V1RC10 activation.

Serotonin hydrochloride

153-98-0sc-201146
sc-201146A
100 mg
1 g
$118.00
$187.00
15
(1)

5-HT receptor agonist that can stimulate adenylate cyclase and increase cAMP levels, activating PKA which may lead to V1RC10 activation.