V1RC Activators
V1R Activators are a diverse array of chemical compounds that primarily function by elevating intracellular cyclic AMP (cAMP) levels, a critical second messenger in V1R-related signaling pathways. Compounds such as Forskolin, PGE1, and Pindolol act on the adenylyl cyclase enzyme to increase cAMP production directly or exhibit partial agonist activity leading to a similar outcome. Phosphodiesterase inhibitors like IBMX, Zaprinast, Rolipram, Cilostamide, L-858051, Milrinone, Anagrelide, Sildenafil, and Vinpocetine further amplify V1R signaling by preventing the degradation of cAMP, thus maintaining its high intracellular concentration. Since V1R is directly involved in cAMP-dependent pathways, the elevated levels of cAMP resulting from these activators' actions lead to enhanced signaling efficacy and functional activity of V1R.
Through the concerted action of these activators, V1R is indirectly activated by a sustained increase in the levels of cAMP within the cell, which is a key mediator of its signaling cascade. The specific inhibitors of various phosphodiesterase isoforms, such as IBMX, a non-selective inhibitor, and Zaprinast, Rolipram, Cilostamide, L-858051, Milrinone, Anagrelide, Sildenafil, and Vinpocetine, each target different forms of the enzyme to prevent cAMP breakdown, thereby facilitating the accumulation of cAMP and indirectly enhancing the activity of V1R. Additionally, Pindolol's partial agonist effect on beta-adrenergic receptors can lead to increased cAMP levels under certain conditions, further contributing to the activation of V1R-dependent signaling. Collectively, these chemical activators exploit the fundamental role of cAMP in V1R's signaling pathways to augment the protein's functional activity, ensuring that V1R-mediated processes are carried out more effectively within the cellular environment.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. Elevated cAMP can enhance V1RC function by modulating downstream cAMP-dependent protein kinase (PKA) activity, which can phosphorylate target proteins involved in pathways that V1RC is a part of, thereby enhancing V1RC's activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP and cGMP. By preventing the breakdown of these cyclic nucleotides, IBMX indirectly increases their levels, thereby potentially enhancing V1RC activity through cAMP or cGMP-dependent signaling pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G-protein-coupled receptors, leading to increased intracellular cAMP levels. This rise in cAMP may enhance the functional activity of V1RC by activating PKA and subsequent signaling cascades that V1RC is involved in. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, acting through its G-protein-coupled receptors, especially H2 receptors, can increase intracellular cAMP levels. This enhancement of cAMP signaling could lead to the increased activity of V1RC by stimulating pathways that involve PKA phosphorylation of associated proteins. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways and proteins, potentially enhancing the activity of V1RC if it is involved in calcium-mediated cellular processes. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P) binds to its specific G-protein-coupled receptors, triggering signaling cascades that can lead to the activation of pathways involving V1RC, thereby enhancing V1RC activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol that has been shown to modulate various signaling pathways, such as those involving kinases. This modulation could upregulate the activity of V1RC if it is part of kinase-regulated pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that increases cytosolic calcium levels by preventing its sequestration into the endoplasmic reticulum. This increase in calcium can enhance V1RC activity if V1RC is regulated by calcium-dependent signaling. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways. By mimicking cAMP, it can enhance the activity of V1RC if V1RC functions are modulated by cAMP-responsive elements. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a wide range of target proteins. This activation of PKC could lead to enhanced V1RC activity if V1RC is part of or regulated by pathways involving PKC. | ||||||