UTP23 Inhibitors
The "UTP23 small subunit processome component," commonly referred to as UTP23, is an essential protein component of the small subunit (SSU) processome, a large ribonucleoprotein complex necessary for the early stages of ribosomal biogenesis in eukaryotic cells. This protein is intricately involved in the maturation of the 18S rRNA, a fundamental constituent of the small 40S ribosomal subunit.
UTP23 works in concert with other proteins and snoRNAs within the SSU processome to orchestrate the processing and correct folding of pre-rRNA. The SSU processome is responsible for the intricate series of enzymatic cleavages, modifications, and structural rearrangements required to transform the precursor rRNA (pre-rRNA) into a mature rRNA molecule capable of participating in protein synthesis.The UTP23 protein interacts with other components of the SSU processome, such as U3 snoRNA, and is believed to assist in the recognition and elimination of the superfluous rRNA sequences that are present in the pre-rRNA transcript. This process is critical as it ensures the correct assembly of the rRNA into the ribosome's structure, thereby maintaining the fidelity of protein synthesis.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
This compound binds to DNA and inhibits RNA polymerase, which could reduce UTP23 expression by preventing its transcription. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been shown to inhibit RNA polymerase I, potentially decreasing rRNA synthesis and thus UTP23 expression. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
CX-5461 selectively inhibits RNA polymerase I, potentially leading to reduced transcription of rRNA genes and therefore decreased expression of UTP23 involved in rRNA processing. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
This small molecule binds to RNA polymerase I and disrupts its function, which could lead to diminished UTP23 expression by limiting rRNA transcription. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin, a nucleoside analog, terminates RNA chain elongation and could thereby decrease UTP23 expression by interrupting pre-rRNA synthesis. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA polymerase II, potentially reducing the transcription of UTP23 mRNA. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B inhibits nuclear export by binding to exportin 1, potentially resulting in decreased UTP23 expression due to accumulation of its mRNA in the nucleus. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide inhibits translation initiation, potentially leading to reduced synthesis of UTP23 protein via general downregulation of translation. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
This compound inhibits the initial elongation step of protein synthesis, which could indirectly result in reduced levels of UTP23 protein. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, which, if UTP23 is glycosylated, could affect its stability or expression levels. | ||||||