UTF1 Inhibitors
Chemical inhibitors of UTF1 can modulate its function in cellular processes, particularly in the context of pluripotency and self-renewal. Indirubin, as a cyclin-dependent kinase inhibitor, can suppress the phosphorylation of transcription factors, which are vital for the transcriptional co-activation of UTF1. This leads to a functional inhibition of UTF1 as it limits its coactivator role. Similarly, Y-27632 targets ROCK kinases, whose inhibition can diminish UTF1's integration within pluripotent stem cells by altering the cell's adhesion and cytoskeleton, elements that are important for maintaining a cellular context conducive to UTF1's role. PD98059 and U0126, both targeting MEK enzymes, can disrupt the MAPK/ERK signaling pathway, which plays a significant part in cell differentiation. This disruption can shift the cellular conditions away from those that support UTF1's contribution to pluripotency.
Moreover, chemicals like LY294002 and Wortmannin, which are potent inhibitors of PI3K, disturb the PI3K/Akt signaling pathway, crucial for the maintenance of pluripotency. This disturbance can affect the cellular environment necessary for UTF1's functional role. Thapsigargin, by inhibiting the SERCA pump, disrupts calcium homeostasis in cells, which can impair UTF1's function by altering transcriptional regulation. Gö6976, a selective inhibitor of Protein Kinase C, can modify the cellular landscape by affecting transcriptional regulation mechanisms, indirectly inhibiting UTF1. Rapamycin, an inhibitor of mTOR, induces changes in autophagy and protein translation, potentially leading to conditions that are not conducive for UTF1's function in chromatin remodeling and gene expression. SP600125 inhibits JNK, altering stress responses and transcription factor activities, which can change the conditions necessary for UTF1's role in maintaining pluripotency. Lastly, SB203580 and KN-93, which inhibit p38 MAP kinase and CaMKII respectively, can lead to altered cell differentiation pathways and cell fate decisions, creating an environment that indirectly inhibits UTF1's functionality in the pluripotency network.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $114.00 $525.00 | 4 | |
Indirubin inhibits cyclin-dependent kinases (CDKs), which are pivotal in cell cycle progression and gene transcription. Inhibition of CDKs can suppress the phosphorylation of transcription factors that are essential for UTF1 transcriptional co-activation, thereby functionally inhibiting UTF1 by limiting its coactivator role. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK kinases. By inhibiting ROCK, this chemical can reduce cell adhesion and alter the cytoskeleton, which impacts the cellular context UTF1 requires for its role in maintaining pluripotency. This indirect inhibition can diminish UTF1's functional integration within pluripotent stem cells. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 selectively inhibits MEK, which is upstream of the MAPK/ERK pathway. Since MAPK/ERK signaling is involved in cell differentiation, inhibiting MEK with PD98059 can shift cellular conditions away from a state that supports UTF1 function in pluripotency and self-renewal, thereby inhibiting UTF1's role in these processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of PI3K. PI3K/Akt signaling is crucial for maintaining pluripotency. Inhibition of PI3K with LY294002 can disrupt this signaling pathway, affecting the cellular environment necessary for UTF1's functional role in the pluripotency network, thereby leading to its functional inhibition. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that disrupts calcium homeostasis in cells. Calcium signaling is essential for various cellular processes, including those that regulate transcription factor activities. Disruption of calcium signaling can impair UTF1's function in maintaining pluripotency by altering transcriptional regulation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor, similar to LY294002. It blocks the PI3K/Akt pathway, which is integral to cell survival and pluripotency. Inhibiting this pathway can indirectly inhibit UTF1 by destabilizing the cellular state that supports its function within the pluripotency and self-renewal regulatory network. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Gö6976 is a selective inhibitor of Protein Kinase C (PKC). PKC is involved in controlling several transcription factors and cellular differentiation. Inhibition of PKC can alter the cellular landscape, indirectly inhibiting UTF1 by affecting the transcriptional regulation mechanisms in which UTF1 is implicated. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of both MEK1 and MEK2. Similar to PD98059, U0126 can prevent the activation of MAPK/ERK pathway, thus affecting cell differentiation signaling pathways. Through this action, it indirectly inhibits UTF1 by shifting the cellular state away from conditions favoring UTF1's role in pluripotency. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor and by inhibiting mTOR, this compound can induce autophagy and affect protein translation. Since UTF1 is associated with chromatin remodeling and gene expression in pluripotent cells, rapamycin's action can lead to an environment that is less conducive for UTF1's function in these processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinases), which are involved in stress responses and also influence transcription factors and cell differentiation. Inhibition of JNK signaling can indirectly inhibit UTF1 by changing the transcriptional dynamics and cellular conditions necessary for UTF1’s role in pluripotency. | ||||||