UTF1 Activators
UTF1 activators are a group of compounds that can influence the activity of the UTF1 (undifferentiated embryonic cell transcription factor 1) protein, primarily in the context of pluripotency and stem cell biology. These activators, such as PD0325901, CHIR99021, and SB431542, work indirectly to modulate UTF1 by affecting various cellular processes related to pluripotency and reprogramming.
PD0325901, for instance, is an MEK inhibitor that plays a critical role in supporting pluripotency in stem cells. By inhibiting the MEK pathway, PD0325901 can create a cellular environment conducive to UTF1 activation. UTF1 is closely associated with pluripotency and plays a pivotal role in maintaining the undifferentiated state of embryonic stem cells. Similarly, CHIR99021, a GSK3β inhibitor, contributes to the promotion of stem cell pluripotency. Its indirect effect on UTF1 arises from its involvement in maintaining undifferentiated states. Stem cells cultivated in the presence of CHIR99021 are more likely to exhibit elevated UTF1 expression, aligning with their undifferentiated characteristics. Additionally, compounds like SB431542, an inhibitor of the TGF-β signaling pathway, indirectly boost UTF1 expression as part of a broader pluripotent network. This is achieved by inhibiting signaling pathways that might otherwise hinder pluripotency.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
A GSK3β inhibitor. When promoting stem cell pluripotency, it can indirectly foster conditions that elevate UTF1 expression due to the protein's association with undifferentiated states. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
By inhibiting the TGF-β signaling pathway and aiding pluripotency, it might indirectly boost UTF1 expression as part of the broader pluripotent network. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
By promoting somatic cell reprogramming and the generation of iPSCs, Vitamin C can indirectly elevate the cellular demand for UTF1, a marker of pluripotency. | ||||||
Tranylcypromine | 13492-01-8 | sc-200572 sc-200572A | 1 g 5 g | $175.00 $599.00 | 5 | |
Enhancing reprogramming efficiency may require an increase in UTF1 activity, indirectly elevating its expression to maintain a pluripotent state. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing intracellular cAMP levels and supporting cellular reprogramming, Forskolin can indirectly foster an environment where UTF1 expression is enhanced. | ||||||
3-Deazaneplanocin, HCl salt | 120964-45-6 | sc-351856 sc-351856A sc-351856B | 1 mg 5 mg 10 mg | $256.00 $612.00 $936.00 | 2 | |
By resetting epigenetic marks, DZNep can indirectly bolster the pluripotent state, leading to a potential increase in UTF1 activity. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
As an HDAC inhibitor that enhances reprogramming efficiency, it can indirectly create conditions favorable for heightened UTF1 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Influencing epigenetic modifications can have indirect effects on pluripotency markers. Thus, 5-Azacytidine might enhance UTF1's role in maintaining the undifferentiated state. | ||||||
TTNPB | 71441-28-6 | sc-203303 sc-203303A sc-203303B | 10 mg 25 mg 50 mg | $210.00 $347.00 $640.00 | 20 | |
While primarily involved in differentiation, in certain contexts, it can indirectly influence pluripotency. This might lead to modulation of UTF1 expression depending on the balance of differentiation and pluripotency signals. | ||||||