TTNPB (CAS 71441-28-6)
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Available in US only.
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TTNPB (4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic Acid) is a synthetic stilbene analog of retinoic acid that acts as a potent retinoic acid receptor (RAR) agonist (EC50 = 21 nM, 4.0 nM, and 2.4 nM for RARalpha, RARbeta, and RARgamma, respectively). These receptors are part of the nuclear receptor family and play a role in regulating gene expression involved in cell differentiation, proliferation, and apoptosis. By binding to RARs, TTNPB can mimic the effects of retinoic acid, a natural form of vitamin A, influencing the transcriptional activity of genes that are pivotal for development, homeostasis, and metabolic processes. The specificity of TTNPB for retinoic acid receptors makes it useful in the study of retinoid signaling pathways. It has been utilized to investigate the molecular mechanisms underlying cell differentiation, particularly in systems where retinoid-induced differentiation plays a key role.
TTNPB (CAS 71441-28-6) References
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- Programming of ES cells and reprogramming of fibroblasts into renal lineage-like cells. | Mansoori-Moghadam, Z., et al. 2019. Exp Cell Res. 379: 225-234. PMID: 30981668
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TTNPB, 10 mg | sc-203303 | 10 mg | $206.00 | |||
| US: Only available in the US | ||||||
TTNPB, 25 mg | sc-203303A | 25 mg | $340.00 | |||
| US: Only available in the US | ||||||
TTNPB, 50 mg | sc-203303B | 50 mg | $562.00 | |||
| US: Only available in the US | ||||||